Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study

Geoff D.E. Cuvelier; Eneida R. Nemecek; Justin T. Wahlstrom; Andrew C. Harris; Michael A. Pulsipher; Victor Lewis; Henrique Bittencourt; Sung Won Choi; Carrie L. Kitko; Emi Caywood; Monica Bhatia; Kmberly Kasow; David A. Jacobsohn; Benjamin R. Oshrine; Albert Kheradpour; Sonali Chaudhury; Joseph H. Chewning; Tal Schechter; Allyson Flower; Don W. Coulter; Michael Joyce; Sureyya Savasan; Anna Pawlowska; Gail Megason; David Mitchell; Alexandra Cheerva; Amina Kariminia; Anat Halevy; Kirk R. Schultz

doi:10.1016/J.BBMT.2017.12.030

Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study

Geoff D.E. Cuvelier, Eneida R. Nemecek, Justin T. Wahlstrom, Andrew C. Harris, Michael A. Pulsipher, Victor Lewis, Henrique Bittencourt, Sung Won Choi, Carrie L. Kitko, Emi Caywood, Monica Bhatia, Kmberly Kasow, David A. Jacobsohn, Benjamin R. Oshrine, Albert Kheradpour, Sonali Chaudhury, Joseph H. Chewning, Tal Schechter, Allyson Flower, Don W. CoulterMichael Joyce, Sureyya Savasan, Anna Pawlowska, Gail Megason, David Mitchell, Alexandra Cheerva, Amina Kariminia, Anat Halevy, Kirk R. Schultz

Pediatric Hematology/Oncology Division

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Original language	American English
Journal	Biology of Blood and Marrow Transplantation
Volume	24
DOIs	https://doi.org/10.1016/J.BBMT.2017.12.030
State	Published - Mar 1 2018

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Immunology and Infectious Disease
Medicine and Health Sciences

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Cuvelier, G. D. E., Nemecek, E. R., Wahlstrom, J. T., Harris, A. C., Pulsipher, M. A., Lewis, V., Bittencourt, H., Choi, S. W., Kitko, C. L., Caywood, E., Bhatia, M., Kasow, K., Jacobsohn, D. A., Oshrine, B. R., Kheradpour, A., Chaudhury, S., Chewning, J. H., Schechter, T., Flower, A., ... Schultz, K. R. (2018). Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study. Biology of Blood and Marrow Transplantation, 24. https://doi.org/10.1016/J.BBMT.2017.12.030

Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study. / Cuvelier, Geoff D.E.; Nemecek, Eneida R.; Wahlstrom, Justin T. et al.
In: Biology of Blood and Marrow Transplantation, Vol. 24, 01.03.2018.

Research output: Contribution to journal › Article › peer-review

Cuvelier, GDE, Nemecek, ER, Wahlstrom, JT, Harris, AC, Pulsipher, MA, Lewis, V, Bittencourt, H, Choi, SW, Kitko, CL, Caywood, E, Bhatia, M, Kasow, K, Jacobsohn, DA, Oshrine, BR, Kheradpour, A, Chaudhury, S, Chewning, JH, Schechter, T, Flower, A, Coulter, DW, Joyce, M, Savasan, S, Pawlowska, A, Megason, G, Mitchell, D, Cheerva, A, Kariminia, A, Halevy, A & Schultz, KR 2018, 'Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study', Biology of Blood and Marrow Transplantation, vol. 24. https://doi.org/10.1016/J.BBMT.2017.12.030

Cuvelier GDE, Nemecek ER, Wahlstrom JT, Harris AC, Pulsipher MA, Lewis V et al. Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study. Biology of Blood and Marrow Transplantation. 2018 Mar 1;24. doi: 10.1016/J.BBMT.2017.12.030

Cuvelier, Geoff D.E. ; Nemecek, Eneida R. ; Wahlstrom, Justin T. et al. / Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study. In: Biology of Blood and Marrow Transplantation. 2018 ; Vol. 24.

@article{c7370911e03b48a8a5d0147956835145,

title = "Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study",

author = "Cuvelier, {Geoff D.E.} and Nemecek, {Eneida R.} and Wahlstrom, {Justin T.} and Harris, {Andrew C.} and Pulsipher, {Michael A.} and Victor Lewis and Henrique Bittencourt and Choi, {Sung Won} and Kitko, {Carrie L.} and Emi Caywood and Monica Bhatia and Kmberly Kasow and Jacobsohn, {David A.} and Oshrine, {Benjamin R.} and Albert Kheradpour and Sonali Chaudhury and Chewning, {Joseph H.} and Tal Schechter and Allyson Flower and Coulter, {Don W.} and Michael Joyce and Sureyya Savasan and Anna Pawlowska and Gail Megason and David Mitchell and Alexandra Cheerva and Amina Kariminia and Anat Halevy and Schultz, {Kirk R.}",

note = "Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express na{\"i}ve and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD.",

year = "2018",

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day = "1",

doi = "10.1016/J.BBMT.2017.12.030",

language = "American English",

volume = "24",

journal = "Biology of Blood and Marrow Transplantation",

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TY - JOUR

T1 - Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study

AU - Cuvelier, Geoff D.E.

AU - Nemecek, Eneida R.

AU - Wahlstrom, Justin T.

AU - Harris, Andrew C.

AU - Pulsipher, Michael A.

AU - Lewis, Victor

AU - Bittencourt, Henrique

AU - Choi, Sung Won

AU - Kitko, Carrie L.

AU - Caywood, Emi

AU - Bhatia, Monica

AU - Kasow, Kmberly

AU - Jacobsohn, David A.

AU - Oshrine, Benjamin R.

AU - Kheradpour, Albert

AU - Chaudhury, Sonali

AU - Chewning, Joseph H.

AU - Schechter, Tal

AU - Flower, Allyson

AU - Coulter, Don W.

AU - Joyce, Michael

AU - Savasan, Sureyya

AU - Pawlowska, Anna

AU - Megason, Gail

AU - Mitchell, David

AU - Cheerva, Alexandra

AU - Kariminia, Amina

AU - Halevy, Anat

AU - Schultz, Kirk R.

N1 - Background: Our group and others (Greinix BBMT 2015) have shown that higher proportions of recent thymic emigrants (RTEs: CD4+CD45RA+CD31+) at d100 are a prognostic biomarker for chronic GvHD in adults. We sought to understand whether RTEs, as well as regulatory T cells (CD4+CD25+CD127Lo) that co-express naïve and recently emigrated markers (CD45RA+CD31+; Treg RTEs) were prognostic at d100 for pediatric cGvHD.

PY - 2018/3/1

Y1 - 2018/3/1

UR - https://www.bbmt.org/article/S1083-8791(17)30919-9/fulltext

U2 - 10.1016/J.BBMT.2017.12.030

DO - 10.1016/J.BBMT.2017.12.030

M3 - Article

VL - 24

JO - Biology of Blood and Marrow Transplantation

JF - Biology of Blood and Marrow Transplantation

ER -

Recent Thymic Emigrants and Tregs Expressing CD31 and CD45RA Are Decreased at Day 100 and Prognostic for Chronic GvHD in Children: Results From the Applied Biomarkers of Late Effects (ABLE)/Pediatric Blood and Marrow Transplant Consortium 1202 Study

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