Recent advances in CAR-T cell engineering

Ruihao Huang; Xiaoping Li; Yundi He; Wen Zhu; Lei Gao; Yao Liu; Li Gao; Qin Wen; Jiang F. Zhong; Cheng Zhang; Xi Zhang

doi:10.1186/s13045-020-00910-5

Recent advances in CAR-T cell engineering

Ruihao Huang, Xiaoping Li, Yundi He, Wen Zhu, Lei Gao, Yao Liu, Li Gao, Qin Wen, Jiang F. Zhong, Cheng Zhang, Xi Zhang

Research output: Contribution to journal › Review article › peer-review

Original language	English
Article number	86
Pages (from-to)	86
Journal	Journal of Hematology and Oncology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s13045-020-00910-5
State	Published - Jul 2 2020
Externally published	Yes

ASJC Scopus Subject Areas

Hematology
Molecular Biology
Oncology
Cancer Research

Keywords

CAR-T cell therapy
Hematological malignancies
Immune therapy
Chemotaxis, Leukocyte
Receptors, Chemokine/immunology
Antigens, Neoplasm/immunology
Humans
Tumor Microenvironment
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy
Neoplasms/therapy
Immunotherapy, Adoptive/methods
Protein Engineering
Protein Domains
Cytokines/metabolism
CD28 Antigens/chemistry
Transduction, Genetic
T-Lymphocytes/immunology
Receptors, Chimeric Antigen/agonists
Antigens, CD19/genetics
Clinical Trials as Topic
Lymphoma, Large B-Cell, Diffuse/therapy
Genetic Vectors/genetics
Protein Binding
T-Cell Antigen Receptor Specificity
Lentivirus/genetics
Cell Engineering/trends

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10.1186/s13045-020-00910-5

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title = "Recent advances in CAR-T cell engineering",

keywords = "CAR-T cell therapy, Hematological malignancies, Immune therapy, Chemotaxis, Leukocyte, Receptors, Chemokine/immunology, Antigens, Neoplasm/immunology, Humans, Tumor Microenvironment, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy, Neoplasms/therapy, Immunotherapy, Adoptive/methods, Protein Engineering, Protein Domains, Cytokines/metabolism, CD28 Antigens/chemistry, Transduction, Genetic, T-Lymphocytes/immunology, Receptors, Chimeric Antigen/agonists, Antigens, CD19/genetics, Clinical Trials as Topic, Lymphoma, Large B-Cell, Diffuse/therapy, Genetic Vectors/genetics, Protein Binding, T-Cell Antigen Receptor Specificity, Lentivirus/genetics, Cell Engineering/trends",

author = "Ruihao Huang and Xiaoping Li and Yundi He and Wen Zhu and Lei Gao and Yao Liu and Li Gao and Qin Wen and Zhong, {Jiang F.} and Cheng Zhang and Xi Zhang",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s).",

year = "2020",

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doi = "10.1186/s13045-020-00910-5",

language = "English",

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AU - Huang, Ruihao

AU - Li, Xiaoping

AU - He, Yundi

AU - Zhu, Wen

AU - Gao, Lei

AU - Liu, Yao

AU - Gao, Li

AU - Wen, Qin

AU - Zhong, Jiang F.

AU - Zhang, Cheng

AU - Zhang, Xi

PY - 2020/7/2

Y1 - 2020/7/2

KW - CAR-T cell therapy

KW - Hematological malignancies

KW - Immune therapy

KW - Chemotaxis, Leukocyte

KW - Receptors, Chemokine/immunology

KW - Antigens, Neoplasm/immunology

KW - Humans

KW - Tumor Microenvironment

KW - Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy

KW - Neoplasms/therapy

KW - Immunotherapy, Adoptive/methods

KW - Protein Engineering

KW - Protein Domains

KW - Cytokines/metabolism

KW - CD28 Antigens/chemistry

KW - Transduction, Genetic

KW - T-Lymphocytes/immunology

KW - Receptors, Chimeric Antigen/agonists

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KW - Clinical Trials as Topic

KW - Lymphoma, Large B-Cell, Diffuse/therapy

KW - Genetic Vectors/genetics

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KW - Lentivirus/genetics

KW - Cell Engineering/trends

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Recent advances in CAR-T cell engineering

ASJC Scopus Subject Areas

Keywords

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