TY - JOUR
T1 - Radiation effects in Caenorhabditis elegans, mutagenesis by high and low LET ionizing radiation
AU - Nelson, Gregory A.
AU - Schubert, Wayne W.
AU - Marshall, Tamara M.
AU - Benton, Eric R.
AU - Benton, Eugene V.
N1 - Funding Information:
detectors and E. John Ainsworth, David Baillie and Philip Hartman for their helpful comments on the manuscript. We also express our thanks to the LBL BEVALAC staff for their patient assistance in performing irradiations. The work described in this report was carried out by the Jet Propulsion Laboratory, California Institute of Technology, supported under contract NAS7-918 with the National Aeronautics and Space Administration. A grant of BEVALAC beam time for experiment 751B was provided by the Lawrence Berkeley Laboratory under contract to the Department of Energy. Nematode stocks were obtained from the C. elegans Genetics Center, University of Missouri, supported through contracts with the Department of Health and Human Services, Division of Research Resources and the National Institute on Ageing.
PY - 1989/6
Y1 - 1989/6
N2 - The nematode C. elegans was used to measure the effectiveness of high-energy ionized particles in the induction of 3 types of genetic lesions. Recessive lethal mutations in a 40-map unit autosomal region, sterility, and X-chromosome nondisjunction or damage were investigated. Induction rates were measured as a function of linear energy transfer. LET∞, for 9 ions of atomic number 1-57 accelerated at the BEVALAC accelerator. Linear kinetics were observed for all 3 types of lesions within the dose/fluence ranges tested and varied strongly as a function of particle LET∞. Relative Biological Effectiveness (RBE) values of up to 4.2 were measured and action cross sections were calculated and compared to mutagenic responses in other systems.
AB - The nematode C. elegans was used to measure the effectiveness of high-energy ionized particles in the induction of 3 types of genetic lesions. Recessive lethal mutations in a 40-map unit autosomal region, sterility, and X-chromosome nondisjunction or damage were investigated. Induction rates were measured as a function of linear energy transfer. LET∞, for 9 ions of atomic number 1-57 accelerated at the BEVALAC accelerator. Linear kinetics were observed for all 3 types of lesions within the dose/fluence ranges tested and varied strongly as a function of particle LET∞. Relative Biological Effectiveness (RBE) values of up to 4.2 were measured and action cross sections were calculated and compared to mutagenic responses in other systems.
KW - Action cross sections
KW - Caenorhabditis elegans
KW - Dose-response curves
KW - High LET ionizing radiation
KW - Lethal mutation
KW - Nematode
KW - Relative Biological Effectiveness
UR - https://www.scopus.com/pages/publications/20244380128
UR - https://www.scopus.com/pages/publications/20244380128#tab=citedBy
U2 - 10.1016/0027-5107(89)90070-5
DO - 10.1016/0027-5107(89)90070-5
M3 - Article
C2 - 2733713
SN - 0027-5107
VL - 212
SP - 181
EP - 192
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 2
ER -