R4 Rgs Subfamily Proteins Negatively Regulates SDF-1/CXCR4 Signaling in CD34+ Hematopoietic Stem and Progenitor Cells

Kam Tong Leung; Yorky Tsin Sik Wong; Karen Li; Kathy Yuen Yee Chan; Xiao-Bing Zhang; Ting Fan Leung; Pak Cheung Ng; Chi Kong Li; Xiaobing Zhang

R4 Rgs Subfamily Proteins Negatively Regulates SDF-1/CXCR4 Signaling in CD34+ Hematopoietic Stem and Progenitor Cells

Kam Tong Leung
, Yorky Tsin Sik Wong
, Karen Li
, Kathy Yuen Yee Chan
, Xiao-Bing Zhang
, Ting Fan Leung
, Pak Cheung Ng
, Chi Kong Li
, Xiaobing Zhang

Research output: Contribution to journal › Article › peer-review

Original language	American English
Journal	Blood
Volume	128
State	Published - Dec 2 2016

Disciplines

Biology
Molecular Biology
Immunology and Infectious Disease

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@article{91d91fcb7ebc46c7801fe285f5d90977,

title = "R4 Rgs Subfamily Proteins Negatively Regulates SDF-1/CXCR4 Signaling in CD34+ Hematopoietic Stem and Progenitor Cells",

author = "Leung, \{Kam Tong\} and Wong, \{Yorky Tsin Sik\} and Karen Li and Chan, \{Kathy Yuen Yee\} and Xiao-Bing Zhang and Leung, \{Ting Fan\} and Ng, \{Pak Cheung\} and Li, \{Chi Kong\} and Xiaobing Zhang",

note = "RGS family proteins are known to negatively regulate G-protein-coupled receptor signaling through their GTPase-accelerating activity. In several types of hematopoietic cells (e.g., B lymphocytes and megakaryocytes), responses to stromal cell-derived factor-1 (SDF-1) are subjected to regulation by R4 subfamily RGS proteins. However, their expression patterns and functional roles in hematopoietic stem and progenitor cells (HSC) are poorly characterized.",

year = "2016",

month = dec,

day = "2",

language = "American English",

volume = "128",

journal = "Blood",

}

TY - JOUR

T1 - R4 Rgs Subfamily Proteins Negatively Regulates SDF-1/CXCR4 Signaling in CD34+ Hematopoietic Stem and Progenitor Cells

AU - Leung, Kam Tong

AU - Wong, Yorky Tsin Sik

AU - Li, Karen

AU - Chan, Kathy Yuen Yee

AU - Zhang, Xiao-Bing

AU - Leung, Ting Fan

AU - Ng, Pak Cheung

AU - Li, Chi Kong

AU - Zhang, Xiaobing

N1 - RGS family proteins are known to negatively regulate G-protein-coupled receptor signaling through their GTPase-accelerating activity. In several types of hematopoietic cells (e.g., B lymphocytes and megakaryocytes), responses to stromal cell-derived factor-1 (SDF-1) are subjected to regulation by R4 subfamily RGS proteins. However, their expression patterns and functional roles in hematopoietic stem and progenitor cells (HSC) are poorly characterized.

PY - 2016/12/2

Y1 - 2016/12/2

UR - http://www.bloodjournal.org/content/128/22/5048?sso-checked=true

M3 - Article

VL - 128

JO - Blood

JF - Blood

ER -

R4 Rgs Subfamily Proteins Negatively Regulates SDF-1/CXCR4 Signaling in CD34+ Hematopoietic Stem and Progenitor Cells

Disciplines

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