Abstract
OBJECTIVE: To examine the effect of cisapride on the corrected QT (QTc) interval in infants over a 14-day period.
STUDY DESIGN: A prospective cohort study of infants receiving cisapride (0.8 mg/kg per day). Twelve-lead electrocardiograms were obtained before and 3, 5, 7, and 14 days after cisapride initiation.
RESULTS: Fifty infants completed the study; none had arrhythmias. Fifteen of 50 infants (30%) developed QTc interval > or =450 msec; QTc interval normalized in 13 of 15 infants. Infants with QTc interval on day 3 > or =2 standard deviations above the mean baseline QTc interval (401+40 msec) were more likely to develop prolonged QTc interval (p<0.0001).
CONCLUSION: QTc interval prolongation was noted in 30% of infants. Subsequently, the majority of those infants had QTc interval normalization by day 14 of cisapride therapy. QTc interval 3 days following cisapride initiation may identify infants at risk for transient QTc interval prolongation. With appropriate monitoring, hospitalized infants receiving cisapride may have improved gastrointestinal motility without cardiac morbidity.
| Original language | English |
|---|---|
| Pages (from-to) | 144-148 |
| Number of pages | 5 |
| Journal | Journal of perinatology : official journal of the California Perinatal Association |
| Volume | 22 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2002 |
ASJC Scopus Subject Areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology
Keywords
- Prospective Studies
- Drug Administration Schedule
- Follow-Up Studies
- Risk Assessment
- Gastrointestinal Motility/drug effects
- Humans
- Probability
- Male
- Treatment Outcome
- Dose-Response Relationship, Drug
- Esophageal Motility Disorders/diagnosis
- Analysis of Variance
- Cisapride/administration & dosage
- Intensive Care Units, Neonatal
- Infant, Premature
- Electrocardiography
- Female
- Infant, Newborn
- Cohort Studies
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