Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

TY - JOUR

T1 - Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

AU - Raja, Anju M.

AU - Xu, Shuoyu

AU - Sun, Wanxin

AU - Zhou, Jianbiao

AU - Tai, Dean C. S.

AU - Chen, Chien-Shing

AU - Rajapakse, Jagath C.

AU - So, Peter T. C.

AU - Yu, Hanry

N1 - Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy.

PY - 2010/10/1

Y1 - 2010/10/1

UR - https://dspace.mit.edu/openaccess-disseminate/1721.1/64972

M3 - Article

JO - SPIE

JF - SPIE

ER -