@article{43cc5ddc768f412aaf3b597971a759ed,
title = "Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy",
author = "Raja, {Anju M.} and Shuoyu Xu and Wanxin Sun and Jianbiao Zhou and Tai, {Dean C. S.} and Chien-Shing Chen and Rajapakse, {Jagath C.} and So, {Peter T. C.} and Hanry Yu",
note = "Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy.",
year = "2010",
month = oct,
day = "1",
language = "American English",
journal = "SPIE",
}