Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo

Alisan Kayabolen; Ugur Akcan; Doğancan Özturan; Hivda Ulbegi-Polat; Gizem Nur Sahin; Nareg Pinarbasi-Degirmenci; Canan Bayraktar; Gizem Soyler; Ehsan Sarayloo; Elif Nurtop; Berna Ozer; Gulen Guney-Esken; Tayfun Barlas; Ismail Selim Yildirim; Ozlem Dogan; Sercin Karahuseyinoglu; Nathan A. Lack; Mehmet Kaya; Cem Albayrak; Fusun Can; Ihsan Solaroglu; Tugba Bagci-Onder

doi:10.1002/advs.202201294

Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo

Alisan Kayabolen, Ugur Akcan, Doğancan Özturan, Hivda Ulbegi-Polat, Gizem Nur Sahin, Nareg Pinarbasi-Degirmenci, Canan Bayraktar, Gizem Soyler, Ehsan Sarayloo, Elif Nurtop, Berna Ozer, Gulen Guney-Esken, Tayfun Barlas, Ismail Selim Yildirim, Ozlem Dogan, Sercin Karahuseyinoglu, Nathan A. Lack, Mehmet Kaya, Cem Albayrak, Fusun CanIhsan Solaroglu, Tugba Bagci-Onder

Physiology Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	2201294
Journal	Advanced Science
Volume	9
Issue number	27
DOIs	https://doi.org/10.1002/advs.202201294
State	Published - Sep 23 2022

ASJC Scopus Subject Areas

Medicine (miscellaneous)
General Chemical Engineering
General Materials Science
Biochemistry, Genetics and Molecular Biology (miscellaneous)
General Engineering
General Physics and Astronomy

Keywords

MoonTag
SARS-CoV-2
SunTag
decoy receptors
escape mutations
multimerization
neutralization
sACE2

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Kayabolen, A., Akcan, U., Özturan, D., Ulbegi-Polat, H., Sahin, G. N., Pinarbasi-Degirmenci, N., Bayraktar, C., Soyler, G., Sarayloo, E., Nurtop, E., Ozer, B., Guney-Esken, G., Barlas, T., Yildirim, I. S., Dogan, O., Karahuseyinoglu, S., Lack, N. A., Kaya, M., Albayrak, C., ... Bagci-Onder, T. (2022). Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo. Advanced Science, 9(27), Article 2201294. https://doi.org/10.1002/advs.202201294

Kayabolen, A, Akcan, U, Özturan, D, Ulbegi-Polat, H, Sahin, GN, Pinarbasi-Degirmenci, N, Bayraktar, C, Soyler, G, Sarayloo, E, Nurtop, E, Ozer, B, Guney-Esken, G, Barlas, T, Yildirim, IS, Dogan, O, Karahuseyinoglu, S, Lack, NA, Kaya, M, Albayrak, C, Can, F, Solaroglu, I & Bagci-Onder, T 2022, 'Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo', Advanced Science, vol. 9, no. 27, 2201294. https://doi.org/10.1002/advs.202201294

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AU - Ulbegi-Polat, Hivda

AU - Sahin, Gizem Nur

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Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo

ASJC Scopus Subject Areas

Keywords

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