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Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

  • Harvey S. Hahn
  • , Yehia Marreez
  • , Amy Odley
  • , Amber Sterbling
  • , Martin G. Yussman
  • , K. Chad Hilty
  • , Ilona Bodi
  • , Stephen B. Liggett
  • , Arnold Schwartz
  • , Gerald W. Dorn

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1111-1119
Number of pages9
JournalCirculation Research
Volume93
Issue number11
DOIs
StatePublished - Nov 28 2003
Externally publishedYes

ASJC Scopus Subject Areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Keywords

  • Interstitial fibrosis
  • Protein kinase C
  • Restrictive cardiomyopathy
  • Systolic and diastolic heart failure
  • Diastole
  • Systole
  • Enzyme Inhibitors/pharmacology
  • Signal Transduction/physiology
  • Protein Kinase C/antagonists & inhibitors
  • Adrenergic beta-Agonists/pharmacology
  • Protein Transport/genetics
  • GTP-Binding Protein alpha Subunits, Gq-G11/genetics
  • Protein Kinase C-alpha
  • Disease Models, Animal
  • Enzyme Activation/drug effects
  • Cardiomegaly/enzymology
  • Cell Separation
  • Receptors, Adrenergic, beta/metabolism
  • Myocytes, Cardiac/drug effects
  • Mice, Transgenic
  • Ventricular Dysfunction/drug therapy
  • Patch-Clamp Techniques
  • Animals
  • Peptides/genetics
  • Mice
  • Cardiomyopathies/enzymology

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