TY - CHAP
T1 - Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model.
AU - Pakkianathan, Colleen
AU - Benggon, Michael
AU - Khatibi, Nikan H.
AU - Chen, Hank
AU - Marcantonio, Suzzanne
AU - Applegate, Richard
AU - Tang, Jiping
AU - Zhang, John
N1 - Funding Information:
This study is partially supported by National Institutes of Health grant NS084921.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Neurosurgical procedures are associated with unintentional damage to the brain during surgery, known as surgically induced brain injuries (SBI), which have been implicated in orchestrating structural and neurobehavioral deterioration. Propofol, an established hypnotic anesthetic agent, has been shown to ameliorate neuronal injury when given after injury in a number of experimental brain studies. We tested the hypothesis that propofol pretreatment confers neuroprotection against SBI and will reduce cerebral edema formation and neurobehavioral deficits in our rat population. Sprague-Dawley rats were treated with low- and high-dose propofol 30 min before SBI. At 24 h post injury, brain water content and neurobehavioral assessment was conducted based on previously established models. In vehicle-treated rats, SBI resulted in significant cerebral edema and higher neurological deficit scores compared with sham-operated rats. Low- or high-dose propofol therapy neither reduced cerebral edema nor improved neurologic function. The results suggest that propofol pretreatment fails to provide neuroprotection in SBI rats. However, it is possible that a SBI model with less magnitude of injury or that propofol re-dosing, given the short-acting pharmacokinetic property of propofol, may be needed to provide definitive conclusions.
AB - Neurosurgical procedures are associated with unintentional damage to the brain during surgery, known as surgically induced brain injuries (SBI), which have been implicated in orchestrating structural and neurobehavioral deterioration. Propofol, an established hypnotic anesthetic agent, has been shown to ameliorate neuronal injury when given after injury in a number of experimental brain studies. We tested the hypothesis that propofol pretreatment confers neuroprotection against SBI and will reduce cerebral edema formation and neurobehavioral deficits in our rat population. Sprague-Dawley rats were treated with low- and high-dose propofol 30 min before SBI. At 24 h post injury, brain water content and neurobehavioral assessment was conducted based on previously established models. In vehicle-treated rats, SBI resulted in significant cerebral edema and higher neurological deficit scores compared with sham-operated rats. Low- or high-dose propofol therapy neither reduced cerebral edema nor improved neurologic function. The results suggest that propofol pretreatment fails to provide neuroprotection in SBI rats. However, it is possible that a SBI model with less magnitude of injury or that propofol re-dosing, given the short-acting pharmacokinetic property of propofol, may be needed to provide definitive conclusions.
KW - Organ Size
KW - Rats
KW - Frontal Lobe/surgery
KW - Male
KW - Neuroprotective Agents/pharmacology
KW - Rats, Sprague-Dawley
KW - Brain Injuries/complications
KW - Brain/drug effects
KW - Neurosurgical Procedures
KW - Brain Edema/etiology
KW - Animals
KW - Intraoperative Complications
KW - Behavior, Animal/drug effects
KW - Propofol/pharmacology
KW - Anesthetics, Intravenous/pharmacology
KW - Disease Models, Animal
UR - https://link.springer.com/content/pdf/10.1007%2F978-3-319-18497-5_56.pdf
UR - https://www.mendeley.com/catalogue/a1ce906b-6308-379c-88f0-8384cada3a66/
U2 - 10.1007/978-3-319-18497-5_56
DO - 10.1007/978-3-319-18497-5_56
M3 - Chapter (peer-reviewed)
C2 - 26463969
SN - 978-3-319-18496-8
SN - 978-3-319-36532-9
T3 - Acta Neurochirurgica, Supplementum
SP - 323
EP - 327
BT - Brain Edema XVI
PB - Springer Cham
ER -