Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice

Adrian L. Oblak; Zackary A. Cope; Sara K. Quinney; Ravi S. Pandey; Carla Biesdorf; Andi R. Masters; Kristen D. Onos; Leslie Haynes; Kelly J. Keezer; Jill A. Meyer; Jonathan S. Peters; Scott A. Persohn; Amanda A. Bedwell; Kierra Eldridge; Rachael Speedy; Gabriela Little; Sean Paul Williams; Brenda Noarbe; Andre Obenaus; Michael Sasner; Gareth R. Howell; Gregory W. Carter; Harriet Williams; Bruce T. Lamb; Paul R. Territo; Stacey J. Sukoff Rizzo

doi:10.1002/trc2.12317

Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice

Adrian L. Oblak
, Zackary A. Cope
, Sara K. Quinney
, Ravi S. Pandey
, Carla Biesdorf
, Andi R. Masters
, Kristen D. Onos
, Leslie Haynes
, Kelly J. Keezer
, Jill A. Meyer
, Jonathan S. Peters
, Scott A. Persohn
, Amanda A. Bedwell
, Kierra Eldridge
, Rachael Speedy
, Gabriela Little
, Sean Paul Williams
, Brenda Noarbe
, Andre Obenaus
, Michael Sasner

Gareth R. Howell, Gregory W. Carter, Harriet Williams, Bruce T. Lamb, Paul R. Territo, Stacey J. Sukoff Rizzo

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	e12317
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	8
Issue number	1
DOIs	https://doi.org/10.1002/trc2.12317
State	Published - 2022
Externally published	Yes

ASJC Scopus Subject Areas

Clinical Neurology
Psychiatry and Mental health

Keywords

BACE inhibitor
MODEL-AD
amyloid
mouse model
preclinical testing

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10.1002/trc2.12317

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Oblak, A. L., Cope, Z. A., Quinney, S. K., Pandey, R. S., Biesdorf, C., Masters, A. R., Onos, K. D., Haynes, L., Keezer, K. J., Meyer, J. A., Peters, J. S., Persohn, S. A., Bedwell, A. A., Eldridge, K., Speedy, R., Little, G., Williams, S. P., Noarbe, B., Obenaus, A., ... Sukoff Rizzo, S. J. (2022). Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 8(1), Article e12317. https://doi.org/10.1002/trc2.12317

Oblak, AL, Cope, ZA, Quinney, SK, Pandey, RS, Biesdorf, C, Masters, AR, Onos, KD, Haynes, L, Keezer, KJ, Meyer, JA, Peters, JS, Persohn, SA, Bedwell, AA, Eldridge, K, Speedy, R, Little, G, Williams, SP, Noarbe, B, Obenaus, A, Sasner, M, Howell, GR, Carter, GW, Williams, H, Lamb, BT, Territo, PR & Sukoff Rizzo, SJ 2022, 'Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 8, no. 1, e12317. https://doi.org/10.1002/trc2.12317

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title = "Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice",

keywords = "BACE inhibitor, MODEL-AD, amyloid, mouse model, preclinical testing",

author = "Oblak, \{Adrian L.\} and Cope, \{Zackary A.\} and Quinney, \{Sara K.\} and Pandey, \{Ravi S.\} and Carla Biesdorf and Masters, \{Andi R.\} and Onos, \{Kristen D.\} and Leslie Haynes and Keezer, \{Kelly J.\} and Meyer, \{Jill A.\} and Peters, \{Jonathan S.\} and Persohn, \{Scott A.\} and Bedwell, \{Amanda A.\} and Kierra Eldridge and Rachael Speedy and Gabriela Little and Williams, \{Sean Paul\} and Brenda Noarbe and Andre Obenaus and Michael Sasner and Howell, \{Gareth R.\} and Carter, \{Gregory W.\} and Harriet Williams and Lamb, \{Bruce T.\} and Territo, \{Paul R.\} and \{Sukoff Rizzo\}, \{Stacey J.\}",

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doi = "10.1002/trc2.12317",

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AU - Oblak, Adrian L.

AU - Cope, Zackary A.

AU - Quinney, Sara K.

AU - Pandey, Ravi S.

AU - Biesdorf, Carla

AU - Masters, Andi R.

AU - Onos, Kristen D.

AU - Haynes, Leslie

AU - Keezer, Kelly J.

AU - Meyer, Jill A.

AU - Peters, Jonathan S.

AU - Persohn, Scott A.

AU - Bedwell, Amanda A.

AU - Eldridge, Kierra

AU - Speedy, Rachael

AU - Little, Gabriela

AU - Williams, Sean Paul

AU - Noarbe, Brenda

AU - Obenaus, Andre

AU - Sasner, Michael

AU - Howell, Gareth R.

AU - Carter, Gregory W.

AU - Williams, Harriet

AU - Lamb, Bruce T.

AU - Territo, Paul R.

AU - Sukoff Rizzo, Stacey J.

PY - 2022

Y1 - 2022

KW - BACE inhibitor

KW - MODEL-AD

KW - amyloid

KW - mouse model

KW - preclinical testing

UR - https://www.scopus.com/pages/publications/85145088748

UR - https://www.scopus.com/pages/publications/85145088748#tab=citedBy

U2 - 10.1002/trc2.12317

DO - 10.1002/trc2.12317

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AN - SCOPUS:85145088748

SN - 2352-8737

VL - 8

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

M1 - e12317

ER -

Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice

ASJC Scopus Subject Areas

Keywords

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