Abstract
INTRODUCTION: This study was performed to evaluate the effect of prior voluntary activation of a muscle on the subsequently-recorded compound muscle action potential (CMAP).
METHODS: The CMAPs from the hypothenar, thenar, and extensor digitorum brevis muscles were recorded in 6 healthy volunteers at rest and for up to 30 min following 5 separate epochs of up to 20 s of voluntary muscle activation.
RESULTS: There was consistent, significant (P < 0.02) enhancement of the negative area, amplitude, and duration of the CMAP after activation. The enhancement was maximal, up to 144% of baseline, within about 1 min post-activation; thereafter, the CMAP gradually returned to baseline over about 15 min.
DISCUSSION: Activation of a muscle within several minutes prior to testing enhances the subsequently-recorded CMAP. This observation highlights prior muscle activation as a physiological variable that influences the size of the CMAP during motor nerve conduction studies. Muscle Nerve, 2019.
| Original language | American English |
|---|---|
| Pages (from-to) | 25-31 |
| Number of pages | 7 |
| Journal | Muscle & Nerve |
| Volume | 60 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2019 |
ASJC Scopus Subject Areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)
Keywords
- CMAP
- CMAP Amplitude
- CMAP Area
- Enhancement
- Facilitation
- Muscle Activation
- Pseudo-facilitation
- Muscle, Skeletal/innervation
- Median Nerve/physiology
- Action Potentials/physiology
- Humans
- Male
- Peroneal Nerve/physiology
- Healthy Volunteers
- Neural Conduction/physiology
- Young Adult
- Ulnar Nerve/physiology
- Adult
- Female
- Muscle Contraction/physiology
Disciplines
- Pharmacology
- Medicine and Health Sciences
- Endocrinology, Diabetes, and Metabolism
- Anatomy
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