TY - JOUR
T1 - Prevalence of elevated troponin I in end-stage renal disease patients receiving hemodialysis
AU - Donnino, Michael W.
AU - Karriem-Norwood, Varnada
AU - Rivers, Emanuel P.
AU - Gupta, Ajay
AU - Bryant Nguyen, H.
AU - Jacobsen, Gordon
AU - McCord, James
AU - Tomlanovich, Michael C.
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PY - 2004/9
Y1 - 2004/9
N2 - Objectives Patients with end-stage renal disease (ESRD) who are receiving hemodialysis have an increased incidence of atherosclerotic heart disease. Currently, there is considerable controversy regarding the significance of elevated cardiac troponin I (cTnI) levels in patients with ESRD. The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis. Methods This was a prospective cohort study at an urban hospital outpatient dialysis center. Serum was collected pre- and postdialysis from patients on dialysis at this center over a two-week period. Samples were batched and analyzed for cTnI using the Asxym fluorescent antibody test. An elevated cTnI level was defined as >0.8 ng/dL. Results Predialysis cTnI levels ranged from <0.1 to 0.7 ng/dL, and postdialysis cTnI levels ranged from <0.1 to 0.6 ng/dL. None of the patients had a cTnI level >0.8 ng/dL. Conclusions cTnI levels are not falsely elevated in patients with ESRD on hemodialysis. In a patient with ESRD, myocardial injury should be suspected if his or her cTnI level is >0.8 ng/dL.
AB - Objectives Patients with end-stage renal disease (ESRD) who are receiving hemodialysis have an increased incidence of atherosclerotic heart disease. Currently, there is considerable controversy regarding the significance of elevated cardiac troponin I (cTnI) levels in patients with ESRD. The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis. Methods This was a prospective cohort study at an urban hospital outpatient dialysis center. Serum was collected pre- and postdialysis from patients on dialysis at this center over a two-week period. Samples were batched and analyzed for cTnI using the Asxym fluorescent antibody test. An elevated cTnI level was defined as >0.8 ng/dL. Results Predialysis cTnI levels ranged from <0.1 to 0.7 ng/dL, and postdialysis cTnI levels ranged from <0.1 to 0.6 ng/dL. None of the patients had a cTnI level >0.8 ng/dL. Conclusions cTnI levels are not falsely elevated in patients with ESRD on hemodialysis. In a patient with ESRD, myocardial injury should be suspected if his or her cTnI level is >0.8 ng/dL.
KW - acute coronary syndrome
KW - biomarkers
KW - cardiac enzymes
KW - dialysis
KW - renal failure
KW - troponin
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U2 - 10.1197/j.aem.2004.03.022
DO - 10.1197/j.aem.2004.03.022
M3 - Article
C2 - 15347551
SN - 1069-6563
VL - 11
SP - 979
EP - 981
JO - Academic Emergency Medicine
JF - Academic Emergency Medicine
IS - 9
ER -