TY - JOUR
T1 - Prenatal cocaine exposure abolished ischemic preconditioning-induced protection in adult male rat hearts
T2 - Role of PKCε
AU - Meyer, Kurt D.
AU - Zhang, Haitao
AU - Zhang, Lubo
N1 - Prenatal cocaine exposure in rats resulted in decreased PKCɛ protein expression in the heart of adult male but not female offspring. The present study determined its functional consequence of inhibiting cardioprotection mediated by ischemic preconditioning. Pregnant Sprague-Dawley rats were administered intraperitoneally saline or cocaine (30 mg·kg −1·day −1) from day 15 to day 21 of gestational age.
PY - 2009/5
Y1 - 2009/5
KW - Fetal programming
KW - Ischemia
KW - Protein kinase C
KW - Phosphorylation
KW - Prenatal Exposure Delayed Effects
KW - Ventricular Function, Left/drug effects
KW - Male
KW - Time Factors
KW - Protein Kinase C-epsilon/antagonists & inhibitors
KW - Gene Expression Regulation, Enzymologic/drug effects
KW - Female
KW - Cocaine/administration & dosage
KW - Myocardium/enzymology
KW - Body Weight/drug effects
KW - Down-Regulation
KW - Injections, Intraperitoneal
KW - Rats
KW - Myocardial Infarction/enzymology
KW - Gestational Age
KW - Rats, Sprague-Dawley
KW - RNA, Messenger/metabolism
KW - Pregnancy
KW - Coronary Circulation/drug effects
KW - Animals
KW - Ischemic Preconditioning, Myocardial
KW - Protein Kinase C-delta/metabolism
KW - Myocardial Reperfusion Injury/enzymology
KW - Sex Factors
KW - Protein Kinase Inhibitors/pharmacology
UR - https://www.scopus.com/pages/publications/66149092966
UR - https://www.scopus.com/pages/publications/66149092966#tab=citedBy
UR - https://www.mendeley.com/catalogue/d6ecd689-ff94-36fe-8acd-a6fb191b0f38/
U2 - 10.1152/ajpheart.00898.2008
DO - 10.1152/ajpheart.00898.2008
M3 - Article
C2 - 19286950
SN - 0363-6135
VL - 296
SP - H1566-H1576
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 5
ER -