Precision Stroke Animal Models: the Permanent MCAO Model Should Be the Primary Model, Not Transient MCAO

Devin W. McBride, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

An argument for preclinical stroke research to make more use of the permanent middle cerebral artery occlusion (MCAO) model, rather than transient MCAO, is presented. Despite STAIR recommending permanent MCAO as the primary model, preclinical stroke research has not been listened. In 2012, Hossmann reported that 64% of the treatment studies for MCAO used prompt transient MCAO models and only 36% of the studies used permanent MCAO or gradual transient MCAO (i.e., embolic stroke model). Then, in 2014 and 2015, 88% of published basic science studies on large vessel occlusion used the transient MCAO model. However, this model only represents 2.5–11.3% of large vessel stroke patients. Therefore, the transient MCAO model, which mimics stroke with reperfusion, does not accurately reflect the majority of clinical stroke cases. Thus, once again, the argument for studying permanent MCAO as a primary model is made and supported.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalTranslational Stroke Research
Volume8
Issue number5
DOIs
StatePublished - Oct 1 2017

ASJC Scopus Subject Areas

  • General Neuroscience
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Keywords

  • Animal models
  • Ischemia
  • Middle cerebral artery occlusion
  • Reperfusion
  • Stroke

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