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PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells

  • Winson S. Ho
  • , Michael J. Feldman
  • , Dragan Maric
  • , Lauren Amable
  • , Matthew D. Hall
  • , Gerald M. Feldman
  • , Abhik Ray-Chaudhury
  • , Martin J. Lizak
  • , Juan Carlos Vera
  • , R. Aaron Robison
  • , Zhengping Zhuang
  • , John D. Heiss

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)12447-12463
Number of pages17
JournalOncotarget
Volume7
Issue number11
DOIs
StatePublished - Mar 15 2016
Externally publishedYes

Keywords

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols/pharmacology
  • Bridged Bicyclo Compounds, Heterocyclic/administration & dosage
  • Cell Line, Tumor
  • Cerebellar Neoplasms/drug therapy
  • Cisplatin/administration & dosage
  • Drug Resistance, Neoplasm
  • Drug Synergism
  • Humans
  • Medulloblastoma/drug therapy
  • Mice
  • Mice, SCID
  • Piperazines/administration & dosage
  • Protein Phosphatase 2/antagonists & inhibitors
  • Xenograft Model Antitumor Assays

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