@article{314352799c064d8e80d2652a1e8ab5f1,
title = "Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression",
keywords = "Polyploidy, Humans, Gene Expression Regulation, Neoplastic, DNA Replication, Tumor Suppressor Protein p53/genetics, Mice, SCID, Neoplasms/genetics, Disease Progression, DNA Breaks, Single-Stranded, Animals, DNA Repair, Mice, Inbred NOD, Mice, DNA Damage",
author = "Li Zheng and Huifang Dai and Mian Zhou and Xiaojin Li and Changwei Liu and Zhigang Guo and Xiwei Wu and Jun Wu and Charles Wang and John Zhong and Qin Huang and Julio Garcia-Aguilar and Pfeifer, \{Gerd P.\} and Binghui Shen",
note = "Funding Information: We thank V. Bedell, D. Bobadilla, J. Collins and M. Slovak in the City of Hope Cytogenetics Core Facility for technical assistance with the karyotype analysis and FISH detection of polyploid cells. We thank M. Lee and B. Armstrong in the City of Hope Microscopy Core Facility for assistance with immunofluorescence, TUNEL and X-gal staining. We thank L. Brown in the City of Hope Flow Cytometry Core for assistance with FACS sorting and analysis. We thank Drs. K. Walker, M. Morgan and S. Tseo for editorial assistance. This work was supported by NIH Grants R01 CA085344 and R01 CA073764 to B. H. S, by P30 CA33572 from the National Cancer Institute to City of Hope, and by the Lung Cancer Program of the City of Hope Comprehensive Cancer Center. This work is also based upon work partially supported by the U. S. Army RDECOM Acquisition Center, Natick Contracting Division, Natick, MA, under Contract No: W911QY-10-C-0176.",
year = "2012",
month = may,
day = "8",
doi = "10.1038/ncomms1825",
language = "English",
volume = "3",
journal = "Nature Communications",
issn = "2041-1723",
}