@article{d72efc3389e34d01a7d55f696372615a,
title = "POLAND'S SYNDROME AND LEUK{\AE}MIA",
author = "David Boaz and Mace, \{John W.\} and Gotlin, \{Ronald W.\}",
note = "Funding Information: These data agree with the findings of Schumacher et al.,lo who showed a decrease in the cytoplasmic area in cells of 5 patients with small-cell C.L.L. and increases in the nuclear and cytoplasmic areas in 1 patient with large- cell C.L.L. In c.L.L., the sparsity of the cytoplasm, the regular shape of the nuclei, and the decreased incidence of elongated mitochondria suggest that the lymphocytes in c.L.L. were relatively inactive compared to normal cells. In L.s.L., the large size of the nuclei and cytoplasm, the increased number of elongated mitochondria, and the changes in the nucleoli suggest that the lymphosarcoma cells were more active than normal lymphocytes. These data support the view of Zacharski and Linman that C.L.L. and L.S.L. are two distinct types of leukxmia which should be differentiated in diagnosis. 2 of the L.S.L. patients mentioned here have already died, but none of the C.L.L. patients has died. We are indebted to Mr. Hiroshi Tonaki for the preparation of the electron micrographs, to Mrs. Kazuko Tonaki for the measure- ments on the cells, and to Mr. Edwin N. Asmann for the statisti- cal analysis. The work was supported by U.S. Public Health grant CA-07541 and by grant from the Luekemia Research Foundation.",
year = "1971",
month = feb,
day = "13",
doi = "10.1016/S0140-6736(71)91077-4",
language = "English",
volume = "297",
pages = "349--350",
journal = "The Lancet",
issn = "0140-6736",
number = "7694",
}