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Phosphodiesterase inhibition decreases nuclear factor-κB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia

  • Raul Coimbra
  • , Heidi Melbostad
  • , William Loomis
  • , Maria Tobar
  • , David B. Hoyt

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume59
Issue number3
StatePublished - Sep 2005
Externally publishedYes

ASJC Scopus Subject Areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Keywords

  • Cytokines
  • Endotoxemia
  • I-κB
  • Interleukin-10
  • Intracellular signaling
  • Mortality
  • Nuclear factor-κB
  • Pentoxifylline
  • Peripheral blood mononuclear cells
  • Phosphodiesterase inhibition
  • Sepsis
  • Tumor necrosis factor-α
  • Sepsis/drug therapy
  • Humans
  • Pentoxifylline/pharmacology
  • Male
  • Endotoxemia/drug therapy
  • Dose-Response Relationship, Drug
  • Leukocyte Count
  • Tumor Necrosis Factor-alpha/drug effects
  • Leukocytes, Mononuclear/drug effects
  • Rats
  • NF-kappa B/blood
  • Cytokines/blood
  • Rats, Sprague-Dawley
  • Animals
  • Analysis of Variance
  • Survival Analysis
  • In Vitro Techniques
  • Interleukin-10/metabolism
  • Phosphodiesterase Inhibitors/pharmacology

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