Phosphodiesterase inhibition decreases nuclear factor-κB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia

Raul Coimbra, Heidi Melbostad, William Loomis, Maria Tobar, David B. Hoyt

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume59
Issue number3
DOIs
StatePublished - Sep 2005

ASJC Scopus Subject Areas

  • Surgery
  • Critical Care and Intensive Care Medicine

Keywords

  • Cytokines
  • Endotoxemia
  • I-κB
  • Interleukin-10
  • Intracellular signaling
  • Mortality
  • Nuclear factor-κB
  • Pentoxifylline
  • Peripheral blood mononuclear cells
  • Phosphodiesterase inhibition
  • Sepsis
  • Tumor necrosis factor-α

Cite this