Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy

R. S. Heist; J. R. Molina; W. J. Urba; Hamid R. Mirshahidi; S. Grunberg; J. Maleski; V. Brainerd; L. Leopold; T. J. Lynch

doi:10.1200/jco.2008.26.15_suppl.19004

Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy

R. S. Heist, J. R. Molina, W. J. Urba, Hamid R. Mirshahidi, S. Grunberg, J. Maleski, V. Brainerd, L. Leopold, T. J. Lynch

Hematology/Oncology Division

Research output: Contribution to journal › Meeting abstract › peer-review

Original language	American English
Pages (from-to)	19004-19004
Number of pages	1
Journal	Journal of Clinical Oncology
Volume	26
Issue number	15_suppl
DOIs	https://doi.org/10.1200/jco.2008.26.15_suppl.19004
State	Published - May 20 2008

Disciplines

Medicine and Health Sciences
Oncology
Pathology

Access to Document

10.1200/jco.2008.26.15_suppl.19004License: Unspecified

OpenUrl availability

Full text

Cite this

Heist, R. S., Molina, J. R., Urba, W. J., Mirshahidi, H. R., Grunberg, S., Maleski, J., Brainerd, V., Leopold, L., & Lynch, T. J. (2008). Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy. Journal of Clinical Oncology, 26(15_suppl), 19004-19004. https://doi.org/10.1200/jco.2008.26.15_suppl.19004

Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy. / Heist, R. S.; Molina, J. R.; Urba, W. J. et al.
In: Journal of Clinical Oncology, Vol. 26, No. 15_suppl, 20.05.2008, p. 19004-19004.

Research output: Contribution to journal › Meeting abstract › peer-review

Heist, RS, Molina, JR, Urba, WJ, Mirshahidi, HR, Grunberg, S, Maleski, J, Brainerd, V, Leopold, L & Lynch, TJ 2008, 'Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy', Journal of Clinical Oncology, vol. 26, no. 15_suppl, pp. 19004-19004. https://doi.org/10.1200/jco.2008.26.15_suppl.19004

@article{e535863bee234f2d804ac2d337b4f3f3,

title = "Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy",

author = "Heist, {R. S.} and Molina, {J. R.} and Urba, {W. J.} and Mirshahidi, {Hamid R.} and S. Grunberg and J. Maleski and V. Brainerd and L. Leopold and Lynch, {T. J.}",

note = "Background: Antiapoptotic members of the Bcl-2 protein family are expressed in the tumor tissue of the majority of patients (pts) with small cell lung cancer (SCLC) and are associated with chemo-resistance. AT-101, an oral, pan Bcl-2 family protein inhibitor has demonstrated activity in SCLC models, including those that express Mcl-1 and are resistant to other Bcl-2 inhibitors.",

year = "2008",

month = may,

day = "20",

doi = "10.1200/jco.2008.26.15_suppl.19004",

language = "American English",

volume = "26",

pages = "19004--19004",

journal = "Journal of Clinical Oncology",

number = "15_suppl",

}

TY - JOUR

T1 - Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy

AU - Heist, R. S.

AU - Molina, J. R.

AU - Urba, W. J.

AU - Mirshahidi, Hamid R.

AU - Grunberg, S.

AU - Maleski, J.

AU - Brainerd, V.

AU - Leopold, L.

AU - Lynch, T. J.

N1 - Background: Antiapoptotic members of the Bcl-2 protein family are expressed in the tumor tissue of the majority of patients (pts) with small cell lung cancer (SCLC) and are associated with chemo-resistance. AT-101, an oral, pan Bcl-2 family protein inhibitor has demonstrated activity in SCLC models, including those that express Mcl-1 and are resistant to other Bcl-2 inhibitors.

PY - 2008/5/20

Y1 - 2008/5/20

UR - http://ascopubs.org/doi/10.1200/jco.2008.26.15_suppl.19004

UR - https://www.mendeley.com/catalogue/5697f0f0-5849-364d-9e86-be13551e124a/

U2 - 10.1200/jco.2008.26.15_suppl.19004

DO - 10.1200/jco.2008.26.15_suppl.19004

M3 - Meeting abstract

VL - 26

SP - 19004

EP - 19004

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

IS - 15_suppl

ER -

Phase I/II study of AT-101 in combination with topotecan in patients with relapsed or refractory small cell lung cancer after prior platinum containing first line chemotherapy

Disciplines

Access to Document

OpenUrl availability

Other files and links

Cite this