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Pharmacological- and gene therapy-based inhibition of protein kinase Cα/β enhances cardiac contractility and attenuates heart failure

  • Michael Hambleton
  • , Harvey Hahn
  • , Sven T. Pleger
  • , Matthew C. Kuhn
  • , Raisa Klevitsky
  • , Andrew N. Carr
  • , Thomas F. Kimball
  • , Timothy E. Hewett
  • , Gerald W. Dorn
  • , Walter J. Koch
  • , Jeffery D. Molkentin

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)574-582
Number of pages9
JournalCirculation
Volume114
Issue number6
DOIs
StatePublished - Aug 8 2006
Externally publishedYes

ASJC Scopus Subject Areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Keywords

  • Cardiomyopathy
  • Contractility
  • Heart failure
  • Protein kinase C
  • Genetic Therapy
  • Protein Kinase C beta
  • Cardiac Output, Low/genetics
  • Pyrroles/pharmacology
  • Myocardial Contraction/drug effects
  • Protein Kinase C-alpha/antagonists & inhibitors
  • Male
  • Indoles/pharmacology
  • Myocardium/chemistry
  • Protein Kinase C/antagonists & inhibitors
  • Female
  • Gene Expression Regulation/physiology
  • Cardiomyopathy, Dilated/genetics
  • Enzyme Activation/drug effects
  • Signal Transduction/genetics
  • Rats
  • Calcium/analysis
  • Rats, Sprague-Dawley
  • Mice, Knockout
  • DNA/analysis
  • Myocardial Infarction/etiology
  • Animals
  • Mice

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