Perioperative Neurocognitive Disorders: A Narrative Review of Pathophysiology, Prevention, and Management Strategies

Daniele Salvatore Paternò; Luigi La Via; Antonio Putaggio; Angela Piccolo; Giuseppe Scibilia; Mario Lentini; Antonino Maniaci; Fabrizio Luca; Emilia Concetta Lo Giudice; Massimiliano Sorbello

doi:10.3390/jcm15031253

Perioperative Neurocognitive Disorders: A Narrative Review of Pathophysiology, Prevention, and Management Strategies

Daniele Salvatore Paternò
, Luigi La Via
, Antonio Putaggio
, Angela Piccolo
, Giuseppe Scibilia
, Mario Lentini
, Antonino Maniaci
, Fabrizio Luca
, Emilia Concetta Lo Giudice
, Massimiliano Sorbello

Research output: Contribution to journal › Review article › peer-review

Original language	English
Article number	1253
Journal	Journal of Clinical Medicine
Volume	15
Issue number	3
DOIs	https://doi.org/10.3390/jcm15031253
State	Published - Feb 2026
Externally published	Yes

ASJC Scopus Subject Areas

General Medicine

Keywords

cognitive impairment
elderly surgical patients
multicomponent interventions
neuroinflammation
postoperative cognitive dysfunction
postoperative delirium
preventive strategies
risk stratification

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10.3390/jcm15031253

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title = "Perioperative Neurocognitive Disorders: A Narrative Review of Pathophysiology, Prevention, and Management Strategies",

keywords = "cognitive impairment, elderly surgical patients, multicomponent interventions, neuroinflammation, postoperative cognitive dysfunction, postoperative delirium, preventive strategies, risk stratification",

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doi = "10.3390/jcm15031253",

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AU - Paternò, Daniele Salvatore

AU - Via, Luigi La

AU - Putaggio, Antonio

AU - Piccolo, Angela

AU - Scibilia, Giuseppe

AU - Lentini, Mario

AU - Maniaci, Antonino

AU - Luca, Fabrizio

AU - Giudice, Emilia Concetta Lo

AU - Sorbello, Massimiliano

PY - 2026/2

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KW - cognitive impairment

KW - elderly surgical patients

KW - multicomponent interventions

KW - neuroinflammation

KW - postoperative cognitive dysfunction

KW - postoperative delirium

KW - preventive strategies

KW - risk stratification

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UR - https://www.scopus.com/pages/publications/105030113315#tab=citedBy

U2 - 10.3390/jcm15031253

DO - 10.3390/jcm15031253

M3 - Review article

C2 - 41682934

AN - SCOPUS:105030113315

SN - 2077-0383

VL - 15

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 3

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ER -

Perioperative Neurocognitive Disorders: A Narrative Review of Pathophysiology, Prevention, and Management Strategies

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

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Cite this