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Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms

  • Todd W. Costantini
  • , Jessica Deree
  • , Carrie Y. Peterson
  • , James G. Putnam
  • , Tiffany Woon
  • , William H. Loomis
  • , Vishal Bansal
  • , Raul Coimbra

Research output: Contribution to journal › Article › peer-review

Original languageEnglish
Pages (from-to)82-91
Number of pages10
JournalImmunopharmacology and Immunotoxicology
Volume32
Issue number1
DOIs
StatePublished - Mar 2010
Externally publishedYes

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

Keywords

  • Akt
  • Inflammation
  • MAPK
  • NADPH
  • PMN
  • Sepsis
  • Down-Regulation
  • Humans
  • Pentoxifylline/pharmacology
  • Proto-Oncogene Proteins c-akt/metabolism
  • Respiratory Burst/drug effects
  • MAP Kinase Signaling System/drug effects
  • Neutrophils/drug effects
  • raf Kinases/physiology
  • Cyclic AMP-Dependent Protein Kinases/physiology
  • NADPH Oxidases/metabolism
  • ras Proteins/physiology
  • N-Formylmethionine Leucyl-Phenylalanine/pharmacology
  • Phosphodiesterase Inhibitors/pharmacology

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