PEDF-34 attenuates neurological deficit and suppresses astrocyte-dependent neuroinflammation by modulating astrocyte polarization via 67LR/JNK/STAT1 signaling pathway after subarachnoid hemorrhage in rats

Lei Wu, Yanchao Liu, Qiuguang He, Guangnan Ao, Ningbo Xu, Wangqing He, Xiao Liu, Lei Huang, Qian Yu, Hideki Kanamaru, Siyuan Dong, Shiyi Zhu, Ye Yuan, Mingyang Han, Yeping Ling, Lu Liu, Chenyu Wu, You Zhou, Prativa Sherchan, Jerry J. FloresJiping Tang, Xionghui Chen, Xuying He, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number178
JournalJournal of Neuroinflammation
Volume21
Issue number1
DOIs
StatePublished - Jul 21 2024

ASJC Scopus Subject Areas

  • General Neuroscience
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

Keywords

  • Astrocyte polarization
  • Neuroinflammation
  • Non-integrin 67-kDa laminin receptor
  • Pigment epithelial-derived factor
  • Subarachnoid hemorrhage
  • Astrocytes/drug effects
  • Cell Polarity
  • Nerve Growth Factors/metabolism
  • Signal Transduction
  • STAT1 Transcription Factor/metabolism
  • Cells, Cultured
  • Rats
  • Male
  • Rats, Sprague-Dawley
  • MAP Kinase Signaling System
  • Neuroinflammatory Diseases/drug therapy
  • Animals
  • Serpins/metabolism
  • Subarachnoid Hemorrhage/drug therapy

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