PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats

Anatol Manaenko, Xuejun Sun, Cherine H. Kim, Junhao Yan, Qingyi Ma, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalNeurobiology of Disease
Volume50
Issue number1
DOIs
StatePublished - Feb 2013

ASJC Scopus Subject Areas

  • Neurology

Keywords

  • ASK1
  • Apoptosis
  • Bim
  • JNK
  • PAR-1
  • Surgical brain injury
  • Thrombin
  • Immunohistochemistry
  • MAP Kinase Kinase Kinase 5/antagonists & inhibitors
  • Neurosurgical Procedures/adverse effects
  • Pyrroles/pharmacology
  • Brain Injuries/metabolism
  • Male
  • Quinazolines/pharmacology
  • Brain/surgery
  • Receptor, PAR-1/antagonists & inhibitors
  • MAP Kinase Kinase 4/antagonists & inhibitors
  • Apoptosis/drug effects
  • Rats
  • Thrombin/metabolism
  • Rats, Sprague-Dawley
  • Blotting, Western
  • Brain Edema/etiology
  • Animals
  • Intraoperative Complications/metabolism

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