PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study

Aatur D. Singhi; Abigail I. Wald; Katelyn Smith; Lynn Wolkenstein; Robert D. Bubar; Ricardo Diaz-Aragon; Maria Grupillo; Danielle Guckin; Yi Tak Lai; Randall E. Brand; Kevin McGrath; Walter G. Park; Patrick R. Pfau; Patricio M. Polanco; Nisa Kubiliun; John DeWitt; Jeffrey J. Easler; Aamir Dam; Shaffer R. Mok; Michael B. Wallace; Brian A. Boone; Wallis Marsh; Shyam Thakkar; Kimberly J. Fairley; Elham Afghani; Yasser Bhat; Sanjay Ramrakhiani; John Nasr; Nikhil R. Thiruvengadam; Asif Khalid; Kenneth Fasanella; Jennifer Chennat; Rohit Das; Harkirat Singh; Adam Slivka; Charles Gabbert; Tarek Sawas; Thomas Tielleman; Hendrikus Dutch Vanderveldt; Anna Tavakkoli; Lynette M. Smith; Anju H. Singhi; Sara A. Singhi; Stephanie Romutis; Sultan Mahmood; Amy E. Hosmer; Julia McNabb-Baltar; Anne Marie Lennon; Ralph H. Hruban; Nuha Shaker; Alessandro Paniccia; Amer Zureikat; Kenneth K. Lee; Melanie Ongchin; Herbert Zeh; Rebecca Minter; C. Max Schmidt; Jin He; Marina N. Nikiforova

doi:10.1245/s10434-025-18848-8

PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study

Aatur D. Singhi
, Abigail I. Wald
, Katelyn Smith
, Lynn Wolkenstein
, Robert D. Bubar
, Ricardo Diaz-Aragon
, Maria Grupillo
, Danielle Guckin
, Yi Tak Lai
, Randall E. Brand
, Kevin McGrath
, Walter G. Park
, Patrick R. Pfau
, Patricio M. Polanco
, Nisa Kubiliun
, John DeWitt
, Jeffrey J. Easler
, Aamir Dam
, Shaffer R. Mok
, Michael B. Wallace

Brian A. Boone, Wallis Marsh, Shyam Thakkar, Kimberly J. Fairley, Elham Afghani, Yasser Bhat, Sanjay Ramrakhiani, John Nasr, Nikhil R. Thiruvengadam, Asif Khalid, Kenneth Fasanella, Jennifer Chennat, Rohit Das, Harkirat Singh, Adam Slivka, Charles Gabbert, Tarek Sawas, Thomas Tielleman, Hendrikus Dutch Vanderveldt, Anna Tavakkoli, Lynette M. Smith, Anju H. Singhi, Sara A. Singhi, Stephanie Romutis, Sultan Mahmood, Amy E. Hosmer, Julia McNabb-Baltar, Anne Marie Lennon, Ralph H. Hruban, Nuha Shaker, Alessandro Paniccia, Amer Zureikat, Kenneth K. Lee, Melanie Ongchin, Herbert Zeh, Rebecca Minter, C. Max Schmidt, Jin He, Marina N. Nikiforova

Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	2865-2875
Number of pages	11
Journal	Annals of surgical oncology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1245/s10434-025-18848-8
State	Published - Apr 2026

ASJC Scopus Subject Areas

Surgery
Oncology

Keywords

Intraductal oncocytic papillary neoplasm
Intraductal papillary mucinous neoplasm
Mucinous cystic neoplasm
Pancreatic ductal adenocarcinoma
Pancreatic neuroendocrine tumor
Pseudocyst
Serous cystadenoma

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Singhi, A. D., Wald, A. I., Smith, K., Wolkenstein, L., Bubar, R. D., Diaz-Aragon, R., Grupillo, M., Guckin, D., Lai, Y. T., Brand, R. E., McGrath, K., Park, W. G., Pfau, P. R., Polanco, P. M., Kubiliun, N., DeWitt, J., Easler, J. J., Dam, A., Mok, S. R., ... Nikiforova, M. N. (2026). PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study. Annals of surgical oncology, 33(4), 2865-2875. https://doi.org/10.1245/s10434-025-18848-8

Singhi, AD, Wald, AI, Smith, K, Wolkenstein, L, Bubar, RD, Diaz-Aragon, R, Grupillo, M, Guckin, D, Lai, YT, Brand, RE, McGrath, K, Park, WG, Pfau, PR, Polanco, PM, Kubiliun, N, DeWitt, J, Easler, JJ, Dam, A, Mok, SR, Wallace, MB, Boone, BA, Marsh, W, Thakkar, S, Fairley, KJ, Afghani, E, Bhat, Y, Ramrakhiani, S, Nasr, J, Thiruvengadam, NR, Khalid, A, Fasanella, K, Chennat, J, Das, R, Singh, H, Slivka, A, Gabbert, C, Sawas, T, Tielleman, T, Vanderveldt, HD, Tavakkoli, A, Smith, LM, Singhi, AH, Singhi, SA, Romutis, S, Mahmood, S, Hosmer, AE, McNabb-Baltar, J, Lennon, AM, Hruban, RH, Shaker, N, Paniccia, A, Zureikat, A, Lee, KK, Ongchin, M, Zeh, H, Minter, R, Schmidt, CM, He, J & Nikiforova, MN 2026, 'PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study', Annals of surgical oncology, vol. 33, no. 4, pp. 2865-2875. https://doi.org/10.1245/s10434-025-18848-8

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title = "PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study",

keywords = "Intraductal oncocytic papillary neoplasm, Intraductal papillary mucinous neoplasm, Mucinous cystic neoplasm, Pancreatic ductal adenocarcinoma, Pancreatic neuroendocrine tumor, Pseudocyst, Serous cystadenoma",

author = "Singhi, \{Aatur D.\} and Wald, \{Abigail I.\} and Katelyn Smith and Lynn Wolkenstein and Bubar, \{Robert D.\} and Ricardo Diaz-Aragon and Maria Grupillo and Danielle Guckin and Lai, \{Yi Tak\} and Brand, \{Randall E.\} and Kevin McGrath and Park, \{Walter G.\} and Pfau, \{Patrick R.\} and Polanco, \{Patricio M.\} and Nisa Kubiliun and John DeWitt and Easler, \{Jeffrey J.\} and Aamir Dam and Mok, \{Shaffer R.\} and Wallace, \{Michael B.\} and Boone, \{Brian A.\} and Wallis Marsh and Shyam Thakkar and Fairley, \{Kimberly J.\} and Elham Afghani and Yasser Bhat and Sanjay Ramrakhiani and John Nasr and Thiruvengadam, \{Nikhil R.\} and Asif Khalid and Kenneth Fasanella and Jennifer Chennat and Rohit Das and Harkirat Singh and Adam Slivka and Charles Gabbert and Tarek Sawas and Thomas Tielleman and Vanderveldt, \{Hendrikus Dutch\} and Anna Tavakkoli and Smith, \{Lynette M.\} and Singhi, \{Anju H.\} and Singhi, \{Sara A.\} and Stephanie Romutis and Sultan Mahmood and Hosmer, \{Amy E.\} and Julia McNabb-Baltar and Lennon, \{Anne Marie\} and Hruban, \{Ralph H.\} and Nuha Shaker and Alessandro Paniccia and Amer Zureikat and Lee, \{Kenneth K.\} and Melanie Ongchin and Herbert Zeh and Rebecca Minter and Schmidt, \{C. Max\} and Jin He and Nikiforova, \{Marina N.\}",

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AU - Wald, Abigail I.

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AU - Wolkenstein, Lynn

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AU - Diaz-Aragon, Ricardo

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AU - Guckin, Danielle

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AU - Polanco, Patricio M.

AU - Kubiliun, Nisa

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AU - Easler, Jeffrey J.

AU - Dam, Aamir

AU - Mok, Shaffer R.

AU - Wallace, Michael B.

AU - Boone, Brian A.

AU - Marsh, Wallis

AU - Thakkar, Shyam

AU - Fairley, Kimberly J.

AU - Afghani, Elham

AU - Bhat, Yasser

AU - Ramrakhiani, Sanjay

AU - Nasr, John

AU - Thiruvengadam, Nikhil R.

AU - Khalid, Asif

AU - Fasanella, Kenneth

AU - Chennat, Jennifer

AU - Das, Rohit

AU - Singh, Harkirat

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AU - Sawas, Tarek

AU - Tielleman, Thomas

AU - Vanderveldt, Hendrikus Dutch

AU - Tavakkoli, Anna

AU - Smith, Lynette M.

AU - Singhi, Anju H.

AU - Singhi, Sara A.

AU - Romutis, Stephanie

AU - Mahmood, Sultan

AU - Hosmer, Amy E.

AU - McNabb-Baltar, Julia

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AU - Hruban, Ralph H.

AU - Shaker, Nuha

AU - Paniccia, Alessandro

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AU - Ongchin, Melanie

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AU - Minter, Rebecca

AU - Schmidt, C. Max

AU - He, Jin

AU - Nikiforova, Marina N.

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KW - Intraductal oncocytic papillary neoplasm

KW - Intraductal papillary mucinous neoplasm

KW - Mucinous cystic neoplasm

KW - Pancreatic ductal adenocarcinoma

KW - Pancreatic neuroendocrine tumor

KW - Pseudocyst

KW - Serous cystadenoma

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PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study

ASJC Scopus Subject Areas

Keywords

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