| Original language | English |
|---|---|
| Pages (from-to) | 175-176 |
| Number of pages | 2 |
| Journal | Free Radical Biology and Medicine |
| Volume | 10 |
| Issue number | 3-4 |
| DOIs | |
| State | Published - 1991 |
ASJC Scopus Subject Areas
- Biochemistry
- Physiology (medical)
Keywords
- Cancer
- Free-radical
- Oxidative stress status
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In: Free Radical Biology and Medicine, Vol. 10, No. 3-4, 1991, p. 175-176.
Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Oxidative stress status and cancer
T2 - Methodology applicable for human studies
AU - Messina, Mark J.
N1 - Funding Information: The Diet and Cancer Branch (DCB) is the primary agent within the Cancer Prevention Research Program (CPRP) of the Division of Cancer Prevention and Control, National Cancer Institute for supporting research aimed at reducing cancer incidence and mortality through dietary modification. The DCB program focuses on research and clinical trials that assess the role of specific foods or food groups in the prevention of cancer. Funding Information: Free radical-induced oxidative damage has been implicated in the etiology of a number of diseases,l~ including cancer. 7-13 Epidemiologic findings show antioxidant intake is inversely related to cancer risk. 14'15 Not surprisingly, among the nutrients being investigated by the National Cancer Institute, antioxidants have received particular attention. At present, 13 clinical trials involving antioxidants (selenium, beta carotene, vitamins C and E) are being funded by the CPRP. 16-18 There is, however, relatively little direct human data supporting the oxidative stress status (OSS)-cancer hypthesis. One approach to filling this void is to compare OSS in groups at high and low-risk of cancer. Preliminary data suggest OSS is elevated in a variety of diseases 19 including subjects at increased risk of breast 2° and cervical cancer. 21 A finding that OSS is predictive of cancer risk would provide considerable support for the OSS-cancer hypothesis and provide the nutrition community with a short-term means for evaluating the effectiveness of antioxidant diets. To evaluate methodology for measuring OSS with potential application to human studies and to discuss the relationship between OSS and cancer risk, the DCB sponsored a workshop on February 20, 1990; the proceedings of which form the basis of this symposium.
PY - 1991
Y1 - 1991
KW - Cancer
KW - Free-radical
KW - Oxidative stress status
UR - http://www.scopus.com/inward/record.url?scp=0025973698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025973698&partnerID=8YFLogxK
U2 - 10.1016/0891-5849(91)90072-B
DO - 10.1016/0891-5849(91)90072-B
M3 - Article
C2 - 1864522
AN - SCOPUS:0025973698
SN - 0891-5849
VL - 10
SP - 175
EP - 176
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 3-4
ER -