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Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells

  • Jennifer J. Gardner
  • , Spencer C. Cushen
  • , Renee de Nazare Oliveira da Silva
  • , Jessica L. Bradshaw
  • , Nataliia Hula
  • , Isabelle K. Gorham
  • , Selina M. Tucker
  • , Zhengyang Zhou
  • , Rebecca L. Cunningham
  • , Nicole R. Phillips
  • , Styliani Goulopoulou

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)C1776-C1788
JournalAmerican Journal of Physiology - Cell Physiology
Volume326
Issue number6
DOIs
StatePublished - Jun 2024

ASJC Scopus Subject Areas

  • Physiology
  • Cell Biology

Keywords

  • mitochondrial DNA
  • placenta
  • pregnancy
  • reactive oxygen species
  • trophoblasts
  • Reactive Oxygen Species/metabolism
  • Antimycin A/pharmacology
  • Cell Line
  • Oxidative Stress
  • Mitochondria/metabolism
  • Humans
  • DNA, Mitochondrial/genetics
  • Extracellular Space/metabolism
  • Apoptosis/drug effects
  • Autophagy/drug effects
  • Placenta/metabolism
  • Trophoblasts/metabolism
  • Rotenone/pharmacology
  • Necrosis
  • Pregnancy
  • Female

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