Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

Chengmei Sun; Muhammad Saif Ur Rahman; Budbazar Enkhjargal; Jianhua Peng; Keren Zhou; Zhiyi Xie; Lingyun Wu; Tongyu Zhang; Qiquan Zhu; Jiping Tang; Yujia Zeng; John H. Zhang; Shanshan Xu

doi:10.1016/j.expneurol.2023.114585

Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

Chengmei Sun
, Muhammad Saif Ur Rahman
, Budbazar Enkhjargal
, Jianhua Peng
, Keren Zhou
, Zhiyi Xie
, Lingyun Wu
, Tongyu Zhang
, Qiquan Zhu
, Jiping Tang
, Yujia Zeng
, John H. Zhang
, Shanshan Xu

Physiology and Pharmacology

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	114585
Journal	Experimental Neurology
Volume	371
DOIs	https://doi.org/10.1016/j.expneurol.2023.114585
State	Published - Jan 2024

ASJC Scopus Subject Areas

Neurology
Developmental Neuroscience

Keywords

Early brain injury
Inflammation
Microglia
Osteopontin
Subarachnoid hemorrhage
Microglia/metabolism
Interleukin-10
Neuroinflammatory Diseases
Rats
Anti-Inflammatory Agents/pharmacology
Integrins/metabolism
Rats, Sprague-Dawley
Subarachnoid Hemorrhage/complications
Animals
Tumor Necrosis Factor-alpha/metabolism
Osteopontin/therapeutic use
NF-kappa B/metabolism
RNA, Small Interfering/pharmacology
Disease Models, Animal

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10.1016/j.expneurol.2023.114585

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Sun, C., Rahman, M. S. U., Enkhjargal, B., Peng, J., Zhou, K., Xie, Z., Wu, L., Zhang, T., Zhu, Q., Tang, J., Zeng, Y., Zhang, J. H., & Xu, S. (2024). Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats. Experimental Neurology, 371, Article 114585. https://doi.org/10.1016/j.expneurol.2023.114585

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title = "Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats",

keywords = "Early brain injury, Inflammation, Microglia, Osteopontin, Subarachnoid hemorrhage, Microglia/metabolism, Interleukin-10, Neuroinflammatory Diseases, Rats, Anti-Inflammatory Agents/pharmacology, Integrins/metabolism, Rats, Sprague-Dawley, Subarachnoid Hemorrhage/complications, Animals, Tumor Necrosis Factor-alpha/metabolism, Osteopontin/therapeutic use, NF-kappa B/metabolism, RNA, Small Interfering/pharmacology, Disease Models, Animal",

author = "Chengmei Sun and Rahman, \{Muhammad Saif Ur\} and Budbazar Enkhjargal and Jianhua Peng and Keren Zhou and Zhiyi Xie and Lingyun Wu and Tongyu Zhang and Qiquan Zhu and Jiping Tang and Yujia Zeng and Zhang, \{John H.\} and Shanshan Xu",

year = "2024",

month = jan,

doi = "10.1016/j.expneurol.2023.114585",

language = "English",

volume = "371",

journal = "Experimental Neurology",

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TY - JOUR

T1 - Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

AU - Sun, Chengmei

AU - Rahman, Muhammad Saif Ur

AU - Enkhjargal, Budbazar

AU - Peng, Jianhua

AU - Zhou, Keren

AU - Xie, Zhiyi

AU - Wu, Lingyun

AU - Zhang, Tongyu

AU - Zhu, Qiquan

AU - Tang, Jiping

AU - Zeng, Yujia

AU - Zhang, John H.

AU - Xu, Shanshan

PY - 2024/1

Y1 - 2024/1

KW - Early brain injury

KW - Inflammation

KW - Microglia

KW - Osteopontin

KW - Subarachnoid hemorrhage

KW - Microglia/metabolism

KW - Interleukin-10

KW - Neuroinflammatory Diseases

KW - Rats

KW - Anti-Inflammatory Agents/pharmacology

KW - Integrins/metabolism

KW - Rats, Sprague-Dawley

KW - Subarachnoid Hemorrhage/complications

KW - Animals

KW - Tumor Necrosis Factor-alpha/metabolism

KW - Osteopontin/therapeutic use

KW - NF-kappa B/metabolism

KW - RNA, Small Interfering/pharmacology

KW - Disease Models, Animal

UR - https://www.scopus.com/pages/publications/85175490628

UR - https://www.scopus.com/pages/publications/85175490628#tab=citedBy

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DO - 10.1016/j.expneurol.2023.114585

M3 - Article

C2 - 37884185

AN - SCOPUS:85175490628

SN - 0014-4886

VL - 371

JO - Experimental Neurology

JF - Experimental Neurology

M1 - 114585

ER -

Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

ASJC Scopus Subject Areas

Keywords

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