Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

Chengmei Sun; Muhammad Saif Ur Rahman; Budbazar Enkhjargal; Jianhua Peng; Keren Zhou; Zhiyi Xie; Lingyun Wu; Tongyu Zhang; Qiquan Zhu; Jiping Tang; Yujia Zeng; John H. Zhang; Shanshan Xu

doi:10.1016/j.expneurol.2023.114585

Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu

Physiology Division

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	114585
Journal	Experimental Neurology
Volume	371
DOIs	https://doi.org/10.1016/j.expneurol.2023.114585
State	Published - Jan 2024

ASJC Scopus Subject Areas

Neurology
Developmental Neuroscience

Keywords

Early brain injury
Inflammation
Microglia
Osteopontin
Subarachnoid hemorrhage
Microglia/metabolism
Interleukin-10
Neuroinflammatory Diseases
Rats
Anti-Inflammatory Agents/pharmacology
Integrins/metabolism
Rats, Sprague-Dawley
Subarachnoid Hemorrhage/complications
Animals
Tumor Necrosis Factor-alpha/metabolism
Osteopontin/therapeutic use
NF-kappa B/metabolism
RNA, Small Interfering/pharmacology
Disease Models, Animal

Access to Document

10.1016/j.expneurol.2023.114585

OpenUrl availability

Full text

Cite this

Sun, C., Rahman, M. S. U., Enkhjargal, B., Peng, J., Zhou, K., Xie, Z., Wu, L., Zhang, T., Zhu, Q., Tang, J., Zeng, Y., Zhang, J. H., & Xu, S. (2024). Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats. Experimental Neurology, 371, Article 114585. https://doi.org/10.1016/j.expneurol.2023.114585

@article{084df06672c84879a251b3e231909116,

title = "Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats",

keywords = "Early brain injury, Inflammation, Microglia, Osteopontin, Subarachnoid hemorrhage, Microglia/metabolism, Interleukin-10, Neuroinflammatory Diseases, Rats, Anti-Inflammatory Agents/pharmacology, Integrins/metabolism, Rats, Sprague-Dawley, Subarachnoid Hemorrhage/complications, Animals, Tumor Necrosis Factor-alpha/metabolism, Osteopontin/therapeutic use, NF-kappa B/metabolism, RNA, Small Interfering/pharmacology, Disease Models, Animal",

author = "Chengmei Sun and Rahman, {Muhammad Saif Ur} and Budbazar Enkhjargal and Jianhua Peng and Keren Zhou and Zhiyi Xie and Lingyun Wu and Tongyu Zhang and Qiquan Zhu and Jiping Tang and Yujia Zeng and Zhang, {John H.} and Shanshan Xu",

year = "2024",

month = jan,

doi = "10.1016/j.expneurol.2023.114585",

language = "English",

volume = "371",

journal = "Experimental Neurology",

issn = "0014-4886",

}

TY - JOUR

T1 - Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

AU - Sun, Chengmei

AU - Rahman, Muhammad Saif Ur

AU - Enkhjargal, Budbazar

AU - Peng, Jianhua

AU - Zhou, Keren

AU - Xie, Zhiyi

AU - Wu, Lingyun

AU - Zhang, Tongyu

AU - Zhu, Qiquan

AU - Tang, Jiping

AU - Zeng, Yujia

AU - Zhang, John H.

AU - Xu, Shanshan

PY - 2024/1

Y1 - 2024/1

KW - Early brain injury

KW - Inflammation

KW - Microglia

KW - Osteopontin

KW - Subarachnoid hemorrhage

KW - Microglia/metabolism

KW - Interleukin-10

KW - Neuroinflammatory Diseases

KW - Rats

KW - Anti-Inflammatory Agents/pharmacology

KW - Integrins/metabolism

KW - Rats, Sprague-Dawley

KW - Subarachnoid Hemorrhage/complications

KW - Animals

KW - Tumor Necrosis Factor-alpha/metabolism

KW - Osteopontin/therapeutic use

KW - NF-kappa B/metabolism

KW - RNA, Small Interfering/pharmacology

KW - Disease Models, Animal

UR - http://www.scopus.com/inward/record.url?scp=85175490628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85175490628&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2023.114585

DO - 10.1016/j.expneurol.2023.114585

M3 - Article

C2 - 37884185

AN - SCOPUS:85175490628

SN - 0014-4886

VL - 371

JO - Experimental Neurology

JF - Experimental Neurology

M1 - 114585

ER -

Osteopontin modulates microglial activation states and attenuates inflammatory responses after subarachnoid hemorrhage in rats

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

Other files and links

Cite this