@article{9c829ebf1f7c4d979119579d9e7741a8,
title = "Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit",
keywords = "DNA helicase, DNA replication, Inhibitor, Optimization",
author = "Bing Li and Ramdas Pai and Daniel Aiello and Ming Di and Barnes, \{Marjorie H.\} and Peet, \{Norton P.\} and Bowlin, \{Terry L.\} and Moir, \{Donald T.\}",
note = "Funding Information: We thank Ms. Shawna M. Rotoli and Dr. Subhasis B. Biswas (Department of Molecular Biology, University of Medicine and Dentistry of New Jersey (UMDNJ)) and Dr. Esther E. Biswas-Fliss (UMDNJ and Department of Bioscience Technologies, Jefferson School of Health Professions, Thomas Jefferson University) for providing B. anthracis helicase, for radiometric assays of the B. anthracis helicase inhibition potency, and for helpful discussions. We thank Mr. Steven C. Cardinale at Microbiotix for assistance with the malachite green-based ATPase assay. This work was supported by the National Institutes of Health/National Institute of Allergy and Infectious Diseases ( AI064974 ). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services. ",
year = "2013",
month = jun,
day = "15",
doi = "10.1016/j.bmcl.2013.04.055",
language = "English",
volume = "23",
pages = "3481--3486",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
number = "12",
}