Abstract
Background and Purpose - We report a modified 4-vessel occlusion (4VO) rat model. Method - We used a 1-stage anterior approach for making bilateral hemispheric ischemia. Results - Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. Conclusion - This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes. © 2005 American Heart Association, Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 2212-2214 |
| Number of pages | 3 |
| Journal | Stroke |
| Volume | 36 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2005 |
ASJC Scopus Subject Areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing
Keywords
- Cerebral blood flow
- Cerebral ischemia, global
- Animals
- Brain/anatomy & histology
- Rats
- Male
- Cerebrovascular Circulation
- Rats, Sprague-Dawley
- Brain Ischemia/pathology
- Disease Models, Animal
- Models, Anatomic
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