@article{74e775d8446644efa5ac44355335e3ee,
title = "Novel benzimidazole inhibitors of botulinum neurotoxin/A display enzyme and cell-based potency",
keywords = "Benzimidazole acrylonitrile, Bioterrorism, Botulinum, Drug discovery, High-throughput screening, Hydroxyquinoline, Metalloprotease, Neurotoxins, SNAP-25, Serotype A, Small molecule inhibitors",
author = "Cardinale, \{Steven C.\} and Butler, \{Michelle M.\} and Gordon Ruthel and Jonathan Nuss and Wanner, \{Laura M.\} and Bing Li and Pai, \{Ramdas P.\} and Peet, \{Norton P.\} and Sina Bavari and Bowlin, \{Terry L.\}",
note = "Botulinum Neurotoxins (BoNTs) are used therapeutically and in cosmetics, providing potential for bioterrorist activity, thus driving the search for small-molecule BoNT inhibitors. This report describes a 70,000-compound screen for inhibition of BoNT/A using a FRET assay to detect proteolysis of a peptide substrate. Hits were confirmed, followed by evaluation to determine compound specificity.",
year = "2011",
month = aug,
doi = "10.1504/TBJ.2011.041813",
language = "English",
volume = "2",
pages = "16--29",
journal = "Botulinum Journal",
issn = "1754-7326",
number = "1",
}