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Noninvasive Assessment of β-Secretase Activity Through Click Chemistry-Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

  • Hyoyong Kim
  • , Junseok Lee
  • , Audrey Qian
  • , You Ren Ji
  • , Ryan Zhang
  • , Qixin Hu
  • , Christopher Kazu Williams
  • , Han Yu Chuang
  • , Matthew D. Smalley
  • , Yaya Xu
  • , Liang Gao
  • , Mary C. Mayo
  • , Ting Zhang
  • , Edwin M. Posadas
  • , Zaldy S. Tan
  • , Harry V. Vinters
  • , Keith Vossel
  • , Shino Magaki
  • , Yazhen Zhu
  • , Hsian Rong Tseng

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Article number2415289
JournalAdvanced Science
Volume12
Issue number26
DOIs
StatePublished - Jul 10 2025
Externally publishedYes

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • General Chemical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • General Materials Science
  • General Engineering
  • General Physics and Astronomy

Keywords

  • Alzheimer's disease
  • liquid biopsy
  • neurodegenerative disease
  • neuronal extracellular vesicle
  • β-secretase

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