Nitro-imidazole hypoxia imaging agent

Thomas Lee Collier; Brian A. Duclos; Umesh B. Gangadharmath; Zhiyong Gao; Farhad Karimi; Dhanalakshmi Kasi; Hartmuth C. Kolb; Qianwa Liang; Henry Clifton Padgett; Joseph C. Walsh; Tieming Zhao

Nitro-imidazole hypoxia imaging agent

Thomas Lee Collier (Inventor)
, Brian A. Duclos (Inventor)
, Umesh B. Gangadharmath (Inventor)
, Zhiyong Gao (Inventor)
, Farhad Karimi (Inventor)
, Dhanalakshmi Kasi (Inventor)
, Hartmuth C. Kolb (Inventor)
, Qianwa Liang (Inventor)
, Henry Clifton Padgett (Inventor)
, Joseph C. Walsh (Inventor)
, Tieming Zhao (Inventor)

Research output: Patent

Original language	American English
State	Published - Apr 4 2008
Externally published	Yes

Disciplines

Biochemistry

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@misc{414463c75c18493daf1b1e2d26990a71,

title = "Nitro-imidazole hypoxia imaging agent",

author = "Collier, \{Thomas Lee\} and Duclos, \{Brian A.\} and Gangadharmath, \{Umesh B.\} and Zhiyong Gao and Farhad Karimi and Dhanalakshmi Kasi and Kolb, \{Hartmuth C.\} and Qianwa Liang and Padgett, \{Henry Clifton\} and Walsh, \{Joseph C.\} and Tieming Zhao",

year = "2008",

month = apr,

day = "4",

language = "American English",

type = "Patent",

}

TY - PAT

T1 - Nitro-imidazole hypoxia imaging agent

AU - Collier, Thomas Lee

AU - Duclos, Brian A.

AU - Gangadharmath, Umesh B.

AU - Gao, Zhiyong

AU - Karimi, Farhad

AU - Kasi, Dhanalakshmi

AU - Kolb, Hartmuth C.

AU - Liang, Qianwa

AU - Padgett, Henry Clifton

AU - Walsh, Joseph C.

AU - Zhao, Tieming

N1 - The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.

PY - 2008/4/4

Y1 - 2008/4/4

UR - https://patents.google.com/patent/US7807394B2/en

M3 - Patent

ER -

Nitro-imidazole hypoxia imaging agent

Disciplines

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