Abstract
Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1302-1309 |
| Number of pages | 8 |
| Journal | Current Medicinal Chemistry |
| Volume | 22 |
| Issue number | 10 |
| DOIs | |
| State | Published - Dec 2015 |
ASJC Scopus Subject Areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Organic Chemistry
Keywords
- Granulocyte-colony stimulating factor
- Neuroprotection
- Stroke
- Treatment
- Animals
- Signal Transduction
- Humans
- Granulocyte Colony-Stimulating Factor/chemistry
- Stroke/drug therapy
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