TY - JOUR
T1 - New missions for an old agent
T2 - Granulocyte-colony stimulating factor in the treatment of stroke patients
AU - Solaroglu, Ihsan
AU - Digicaylioglu, Murat
AU - Keles, G. Evren
AU - Zhang, John H.
N1 - Publisher Copyright:
© 2015 Bentham Science Publishers.
PY - 2015/12
Y1 - 2015/12
N2 - Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
AB - Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.
KW - Granulocyte-colony stimulating factor
KW - Neuroprotection
KW - Stroke
KW - Treatment
KW - Animals
KW - Signal Transduction
KW - Humans
KW - Granulocyte Colony-Stimulating Factor/chemistry
KW - Stroke/drug therapy
UR - http://www.scopus.com/inward/record.url?scp=84931269931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931269931&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/e5543809-34f6-3774-b6eb-ab4433e92628/
U2 - 10.2174/0929867322666150209153606
DO - 10.2174/0929867322666150209153606
M3 - Article
C2 - 25666797
SN - 0929-8673
VL - 22
SP - 1302
EP - 1309
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 10
ER -