New missions for an old agent: Granulocyte-colony stimulating factor in the treatment of stroke patients

Ihsan Solaroglu, Murat Digicaylioglu, G. Evren Keles, John H. Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Granulocyte-colony stimulating factor (G-CSF) has a multimodal neuroprotective profile and the cumulative preclinical data from numerous translational studies statistically confirmed the efficacy of G-CSF as a treatment option in ischemic stroke. G-CSF activates anti-apoptotic, antioxidative, and anti-inflammatory signaling pathways and stimulates angiogenesis and neurogenesis. In this review, we summarize the role of G-CSF and the corresponding signal transduction pathways regulated by G-CSF in neuroprotection and discuss its potential as a new drug for stroke treatment.

Original languageEnglish
Pages (from-to)1302-1309
Number of pages8
JournalCurrent Medicinal Chemistry
Volume22
Issue number10
DOIs
StatePublished - Dec 2015

ASJC Scopus Subject Areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

Keywords

  • Granulocyte-colony stimulating factor
  • Neuroprotection
  • Stroke
  • Treatment
  • Animals
  • Signal Transduction
  • Humans
  • Granulocyte Colony-Stimulating Factor/chemistry
  • Stroke/drug therapy

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