Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: A potential role in aortic valve sclerosis

  • Qingzhou Yao
  • , Rui Song
  • , Lihua Ao
  • , Joseph C. Cleveland
  • , David A. Fullerton
  • , Xianzhong Meng

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)C697-C706
JournalAmerican Journal of Physiology - Cell Physiology
Volume312
Issue number6
DOIs
StatePublished - Jun 2017
Externally publishedYes

ASJC Scopus Subject Areas

  • Physiology
  • Cell Biology

Keywords

  • AVIC
  • Akt
  • Fibrogenic response
  • Neurotrophin 3
  • Trk
  • Transcatheter Aortic Valve Replacement
  • Humans
  • Middle Aged
  • Matrix Metalloproteinases/biosynthesis
  • Myofibroblasts/cytology
  • Male
  • Case-Control Studies
  • Sclerosis
  • Aortic Valve/metabolism
  • Cyclin D1/genetics
  • Receptor, trkA/antagonists & inhibitors
  • Female
  • Cell Proliferation/drug effects
  • Calcinosis/genetics
  • Signal Transduction
  • Gene Expression Regulation
  • Aortic Valve Stenosis/genetics
  • Proto-Oncogene Proteins c-akt/antagonists & inhibitors
  • Collagen/biosynthesis
  • Neurotrophin 3/genetics
  • Aged
  • Primary Cell Culture
  • Protein Kinase Inhibitors/pharmacology

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