TY - CHAP
T1 - Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats.
AU - Lekic, Tim
AU - Manaenko, Anatol
AU - Rolland, William
AU - Virbel, Kelly
AU - Hartman, Richard
AU - Tang, Jiping
AU - Zhang, John H.
N1 - Funding Information:
Acknowledgements and Funding This study was partially supported by a grant (NS053407) from the National Institutes of Health to J.H. Zhang. Conflict of interest statement
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: Germinal matrix hemorrhage (GMH) is a devastating neurological disorder of very low birth weight premature infants that leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Melatonin is a potent antioxidant known to reverse free-radical mediated injury in the brain. This study investigated the effect of melatonin treatment after GMH injury. Methods: Clostridial collagenase was infused into the right germinal matrix region of neonatal rats with stereotaxic technique. Cognitive function, sensorimotor ability, cerebral, cardiac and splenic growths were measured in juvenile animals. Results: Systemic melatonin treatment ameliorated cognitive and sensorimotor dysfunction at the juvenile developmental stage. This hormone also normalized brain atrophy, splenomegaly, and cardiac hypertrophy consequences at 1 month after injury. Conclusion: This study supports the role of free radicals in acute neonatal hemorrhagic brain injury. Melatonin is an effective antioxidant that can protect the infant's brain from the post-hemorrhagic consequences of mental retardation and cerebral palsy. Further mechanistic studies are warranted to determine the mechanisms behind these neuroprotective effects. © 2011 Springer-Verlag/Wien.
AB - Background: Germinal matrix hemorrhage (GMH) is a devastating neurological disorder of very low birth weight premature infants that leads to post-hemorrhagic hydrocephalus, cerebral palsy, and mental retardation. Melatonin is a potent antioxidant known to reverse free-radical mediated injury in the brain. This study investigated the effect of melatonin treatment after GMH injury. Methods: Clostridial collagenase was infused into the right germinal matrix region of neonatal rats with stereotaxic technique. Cognitive function, sensorimotor ability, cerebral, cardiac and splenic growths were measured in juvenile animals. Results: Systemic melatonin treatment ameliorated cognitive and sensorimotor dysfunction at the juvenile developmental stage. This hormone also normalized brain atrophy, splenomegaly, and cardiac hypertrophy consequences at 1 month after injury. Conclusion: This study supports the role of free radicals in acute neonatal hemorrhagic brain injury. Melatonin is an effective antioxidant that can protect the infant's brain from the post-hemorrhagic consequences of mental retardation and cerebral palsy. Further mechanistic studies are warranted to determine the mechanisms behind these neuroprotective effects. © 2011 Springer-Verlag/Wien.
KW - Experimental
KW - Melatonin
KW - Neurological deficits
KW - Stroke
KW - Animals, Newborn
KW - Collagenases/adverse effects
KW - Melatonin/therapeutic use
KW - Antioxidants/therapeutic use
KW - Rats
KW - Male
KW - Intracranial Hemorrhages/chemically induced
KW - Atrophy/drug therapy
KW - Cognition Disorders/drug therapy
KW - Dose-Response Relationship, Drug
KW - Pregnancy
KW - Animals
KW - Analysis of Variance
KW - Female
KW - Gait Disorders, Neurologic/drug therapy
KW - Cerebral Cortex/drug effects
KW - Organ Size/drug effects
UR - http://europepmc.org/articles/PMC3569074
UR - https://www.mendeley.com/catalogue/6cc75ee9-907d-384b-abb1-2066d455ada6/
UR - https://www.scopus.com/pages/publications/79960695264
UR - https://www.scopus.com/pages/publications/79960695264#tab=citedBy
U2 - 10.1007/978-3-7091-0693-8_34
DO - 10.1007/978-3-7091-0693-8_34
M3 - Chapter
C2 - 21725756
SN - 9783709106921
SN - 978-3-7091-2007-1
T3 - Acta Neurochirurgica, Supplementum
SP - 201
EP - 206
BT - Intracerebral Hemorrhage Research
PB - Springer Vienna
ER -