Neuroendocrine-Immunology Mechanisms of Subtle Cerebellum Impairment

Cerebellum degeneration and impairment may occur from both clinically obvious and subtle mechanisms. Obvious mechanisms of cerebellum disease include acute onset found with trauma and vascular lesions, compressive signs found with tumor, infectious mechanisms associated with fever and abnormal immune serology, and genetic patterns that have distinct identifying clinical features. Subtle neuroendocrine-immune mechanisms that can impair and degenerate the cerebellum include gluten specific cross-reactivity, Hashimoto’s encephalopathy, hypothyroidism, dysglycemia, subtle cerebellum autoimmunity, paraneoplastic cerebellum syndrome, or toxicological insults to cerebellum granulocytes and Purkinje cells. This paper reviews subtle neuroendocrine-immune mechanisms that insult the cerebellum.