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Multimodality Imaging in Aortic Stenosis: Beyond the Valve - Focusing on the Myocardium

  • Safwan Gaznabi
  • , Jeirym Miranda
  • , Daniel Lorenzatti
  • , Pamela Piña
  • , Senthil S. Balasubramanian
  • , Darshi Desai
  • , Aditya Desai
  • , Edwin C. Ho
  • , Andrea Scotti
  • , Carlos A. Gongora
  • , Aldo L. Schenone
  • , Mario J. Garcia
  • , Azeem Latib
  • , Purvi Parwani
  • , Leandro Slipczuk

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Current guidelines of aortic stenosis (AS) management focus on valve parameters, LV systolic dysfunction, and symptoms; however, emerging data suggest that there may be benefit of aortic valve replacement before it becomes severe by present criteria. Myocardial assessment using novel multimodality imaging techniques exhibits subclinical myocardial injury and remodeling at various stages before guideline-directed interventions, which predicts adverse outcomes. This raises the question of whether implementing serial myocardial assessment should become part of the standard appraisal, thereby identifying high-risk patients aiming to minimize adverse outcomes.

    Original languageEnglish
    Pages (from-to)433-446
    Number of pages14
    JournalCardiology Clinics
    Volume42
    Issue number3
    DOIs
    StatePublished - Aug 2024

    ASJC Scopus Subject Areas

    • Cardiology and Cardiovascular Medicine

    Keywords

    • Aortic stenosis
    • Asymptomatic
    • Discordant
    • Fibrosis
    • Global longitudinal strain
    • Low flow low gradient
    • Myocardium
    • Humans
    • Multimodal Imaging/methods
    • Magnetic Resonance Imaging, Cine/methods
    • Aortic Valve Stenosis/diagnostic imaging
    • Myocardium/pathology
    • Aortic Valve/diagnostic imaging

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