Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors

Stanley A. Tan; Lee S. Berk; Linda G. Tan

doi:10.1016/0885-4505(90)90069-D

Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors

Stanley A. Tan
, Lee S. Berk
, Linda G. Tan

Research output: Contribution to journal › Article › peer-review

Abstract

This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake.

Original language	English
Pages (from-to)	252-258
Number of pages	7
Journal	Biochemical Medicine and Metabolic Biology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/0885-4505(90)90069-D
State	Published - Dec 1990

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism
Biochemistry

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title = "Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors",

abstract = "This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake.",

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AB - This study shows that MIT and DIT stimulate aldosterone secretion. This may be due to their tyrosine hydroxylase inhibitory property. Dopamine abolishes the stimulation. Prolonged MIT administration enhances the stimulation of aldosterone secretion and can cause hypokalemia. Volume expansion reverses the hyperaldosteronism. PRA and blood pressure do not change, even after prolonged MIT intake.

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Modulation of the renin-aldosterone system by iodotyrosines as tyrosine hydroxylase inhibitors

Abstract

ASJC Scopus Subject Areas

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