TY - CHAP
T1 - Modeling of sleep-induced changes in airway function
T2 - Implication for nocturnal worsening of bronchial asthma
AU - Haxhiu, Musa A.
AU - Kc, Prabha
AU - Balan, Kannan V.
AU - Wilson, Christopher G.
AU - Martin, Richard J.
N1 - Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 605) Here we describe the model of sleep-induced worsening of airway function in patients with airway disorders. Our model is based on the noradrenergic pathways that link central neuronal structures responsible for alternating wakefulness and sleep with the neuronal networks regulating the activity of airway-related vagal preganglionic neurons (AVPNs).
PY - 2008
Y1 - 2008
N2 - Here we describe the model of sleep-induced worsening of airway function in patients with airway disorders. Our model is based on the noradrenergic pathways that link central neuronal structures responsible for alternating wakefulness and sleep with the neuronal networks regulating the activity of airway-related vagal preganglionic neurons (AVPNs). Our previous studies showed that cholinergic outflow to the airways depend on the activity of inhibitory inputs to AVPNs. Major inhibitory cell groups, regulating AVPNs discharge, include brainstem noradrenaline (NA)-containing cells receiving projections from the hypothalamic sleep-promoting neurons of the ventrolateral preoptic region (VLPO). When activated, VLPO cells, using GABA and/or galanin as mediators, downregulate the activity of inhibitory NA neurons projecting to AVPNs. Therefore, changes that occur during sleep lead to a shift from inhibitory to excitatory transmission of the AVPNs, thereby increasing cholinergic outflow to the airways. Our model, based on neuroanatomical and molecular studies, and physiology experiments, can be used to explain sleep-related worsening of bronchial asthma and might contribute to development of clinically meaningful treatment for patients with sleep-induced worsening of airway function and respiratory symptoms. © 2008 Springer Science+Business Media, LLC.
AB - Here we describe the model of sleep-induced worsening of airway function in patients with airway disorders. Our model is based on the noradrenergic pathways that link central neuronal structures responsible for alternating wakefulness and sleep with the neuronal networks regulating the activity of airway-related vagal preganglionic neurons (AVPNs). Our previous studies showed that cholinergic outflow to the airways depend on the activity of inhibitory inputs to AVPNs. Major inhibitory cell groups, regulating AVPNs discharge, include brainstem noradrenaline (NA)-containing cells receiving projections from the hypothalamic sleep-promoting neurons of the ventrolateral preoptic region (VLPO). When activated, VLPO cells, using GABA and/or galanin as mediators, downregulate the activity of inhibitory NA neurons projecting to AVPNs. Therefore, changes that occur during sleep lead to a shift from inhibitory to excitatory transmission of the AVPNs, thereby increasing cholinergic outflow to the airways. Our model, based on neuroanatomical and molecular studies, and physiology experiments, can be used to explain sleep-related worsening of bronchial asthma and might contribute to development of clinically meaningful treatment for patients with sleep-induced worsening of airway function and respiratory symptoms. © 2008 Springer Science+Business Media, LLC.
KW - Airway-related vagal preganglionic neurons
KW - Nocturnal asthma
KW - Noradrenergic neurons
KW - Sleep-generating sites
KW - Neurons/physiology
KW - Humans
KW - Airway Resistance/physiology
KW - Wakefulness/physiology
KW - Sleep/physiology
KW - Vagus Nerve/physiopathology
KW - Models, Biological
KW - Models, Neurological
KW - Ganglia/physiopathology
KW - Asthma/physiopathology
KW - Sleep Wake Disorders/etiology
UR - https://link.springer.com/content/pdf/10.1007%2F978-0-387-73693-8_82.pdf
UR - https://www.mendeley.com/catalogue/07a7696b-8023-3201-b9b0-82b7f1ed8032/
U2 - 10.1007/978-0-387-73693-8_82
DO - 10.1007/978-0-387-73693-8_82
M3 - Chapter (peer-reviewed)
C2 - 18085319
SN - 9780387736921
SN - 978-1-4419-2529-9
T3 - Advances in Experimental Medicine and Biology
SP - 469
EP - 474
BT - Advances in Experimental Medicine and Biology
A2 - Poulin, Marc
A2 - Wilson, Richard
PB - Springer New York
ER -