Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage

Ye Yuan; Xiao Yang; Yutong Zhao; Jerry J. Flores; Lei Huang; Lingui Gu; Ruihao Li; Xingyu Zhang; Shiyi Zhu; Siyuan Dong; Hideki Kanamaru; Qiuguang He; Yihao Tao; Kun Yi; Mingyang Han; Xionghui Chen; Lei Wu; John H. Zhang; Zongyi Xie; Jiping Tang

doi:10.1177/0271678X241252110

Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage

Ye Yuan
, Xiao Yang
, Yutong Zhao
, Jerry J. Flores
, Lei Huang
, Lingui Gu
, Ruihao Li
, Xingyu Zhang
, Shiyi Zhu
, Siyuan Dong
, Hideki Kanamaru
, Qiuguang He
, Yihao Tao
, Kun Yi
, Mingyang Han
, Xionghui Chen
, Lei Wu
, John H. Zhang
, Zongyi Xie
, Jiping Tang

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	510-527
Number of pages	18
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	45
Issue number	3
Early online date	Aug 24 2024
DOIs	https://doi.org/10.1177/0271678X241252110
State	Published - Mar 2025

ASJC Scopus Subject Areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

Keywords

Germinal matrix hemorrhage
deferiprone
iron overload
mitochondrial ferritin
neuronal ferroptosis
Up-Regulation/drug effects
Animals, Newborn
Ferritins/metabolism
Mitochondria/metabolism
Deferiprone/pharmacology
Rats
Cell Cycle Proteins/metabolism
Male
Ferroptosis/drug effects
Rats, Sprague-Dawley
Signal Transduction/drug effects
YAP-Signaling Proteins/metabolism
Animals
Neurons/metabolism
Cerebral Hemorrhage/metabolism
Intracellular Signaling Peptides and Proteins/metabolism
Disease Models, Animal

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10.1177/0271678X241252110

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Yuan, Y., Yang, X., Zhao, Y., Flores, J. J., Huang, L., Gu, L., Li, R., Zhang, X., Zhu, S., Dong, S., Kanamaru, H., He, Q., Tao, Y., Yi, K., Han, M., Chen, X., Wu, L., Zhang, J. H., Xie, Z., & Tang, J. (2025). Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage. Journal of Cerebral Blood Flow and Metabolism, 45(3), 510-527. https://doi.org/10.1177/0271678X241252110

Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage. / Yuan, Ye; Yang, Xiao; Zhao, Yutong et al.
In: Journal of Cerebral Blood Flow and Metabolism, Vol. 45, No. 3, 03.2025, p. 510-527.

Research output: Contribution to journal › Article › peer-review

Yuan, Y, Yang, X, Zhao, Y, Flores, JJ , Huang, L, Gu, L, Li, R, Zhang, X, Zhu, S, Dong, S, Kanamaru, H, He, Q, Tao, Y, Yi, K, Han, M, Chen, X, Wu, L, Zhang, JH, Xie, Z & Tang, J 2025, 'Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage', Journal of Cerebral Blood Flow and Metabolism, vol. 45, no. 3, pp. 510-527. https://doi.org/10.1177/0271678X241252110

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title = "Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage",

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Mitochondrial ferritin upregulation by deferiprone reduced neuronal ferroptosis and improved neurological deficits via NDRG1/Yap pathway in a neonatal rat model of germinal matrix hemorrhage

ASJC Scopus Subject Areas

Keywords

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OpenUrl availability

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