Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

Jun Yan; Weilin Xu; Cameron Lenahan; Lei Huang; Umut Ocak; Jing Wen; Gaigai Li; Wei He; Chensheng Le; John H. Zhang; Ligen Mo; Jiping Tang

doi:10.1186/s12987-022-00305-3

Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

Jun Yan, Weilin Xu, Cameron Lenahan, Lei Huang, Umut Ocak, Jing Wen, Gaigai Li, Wei He, Chensheng Le, John H. Zhang, Ligen Mo, Jiping Tang

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	7
Journal	Fluids and Barriers of the CNS
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12987-022-00305-3
State	Published - Jan 21 2022

ASJC Scopus Subject Areas

Neurology
Developmental Neuroscience
Cellular and Molecular Neuroscience

Keywords

Blood–brain barrier
C–C chemokine receptor type 5
Intracerebral hemorrhage
Met-RANTES
rac1 GTP-Binding Protein/drug effects
CCR5 Receptor Antagonists/pharmacology
Male
src-Family Kinases/drug effects
Signal Transduction/drug effects
Chemokine CCL5/administration & dosage
Animals
Blood-Brain Barrier/drug effects
Cerebral Hemorrhage/drug therapy
Mice
Receptors, CCR1/antagonists & inhibitors
Neuropeptides/drug effects

Access to Document

10.1186/s12987-022-00305-3

OpenUrl availability

Full text

Cite this

@article{3bc7a688c2064e36b7d13522125c612f,

title = "Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice",

keywords = "Blood–brain barrier, C–C chemokine receptor type 5, Intracerebral hemorrhage, Met-RANTES, rac1 GTP-Binding Protein/drug effects, CCR5 Receptor Antagonists/pharmacology, Male, src-Family Kinases/drug effects, Signal Transduction/drug effects, Chemokine CCL5/administration & dosage, Animals, Blood-Brain Barrier/drug effects, Cerebral Hemorrhage/drug therapy, Mice, Receptors, CCR1/antagonists & inhibitors, Neuropeptides/drug effects",

author = "Jun Yan and Weilin Xu and Cameron Lenahan and Lei Huang and Umut Ocak and Jing Wen and Gaigai Li and Wei He and Chensheng Le and Zhang, {John H.} and Ligen Mo and Jiping Tang",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = jan,

day = "21",

doi = "10.1186/s12987-022-00305-3",

language = "English",

volume = "19",

journal = "Fluids and Barriers of the CNS",

issn = "2045-8118",

number = "1",

}

TY - JOUR

T1 - Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

AU - Yan, Jun

AU - Xu, Weilin

AU - Lenahan, Cameron

AU - Huang, Lei

AU - Ocak, Umut

AU - Wen, Jing

AU - Li, Gaigai

AU - He, Wei

AU - Le, Chensheng

AU - Zhang, John H.

AU - Mo, Ligen

AU - Tang, Jiping

PY - 2022/1/21

Y1 - 2022/1/21

KW - Blood–brain barrier

KW - C–C chemokine receptor type 5

KW - Intracerebral hemorrhage

KW - Met-RANTES

KW - rac1 GTP-Binding Protein/drug effects

KW - CCR5 Receptor Antagonists/pharmacology

KW - Male

KW - src-Family Kinases/drug effects

KW - Signal Transduction/drug effects

KW - Chemokine CCL5/administration & dosage

KW - Animals

KW - Blood-Brain Barrier/drug effects

KW - Cerebral Hemorrhage/drug therapy

KW - Mice

KW - Receptors, CCR1/antagonists & inhibitors

KW - Neuropeptides/drug effects

UR - http://www.scopus.com/inward/record.url?scp=85123437141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85123437141&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/2b69ee79-9032-36f5-a6a4-a8dc189dab04/

U2 - 10.1186/s12987-022-00305-3

DO - 10.1186/s12987-022-00305-3

M3 - Article

C2 - 35062973

AN - SCOPUS:85123437141

SN - 2045-8118

VL - 19

JO - Fluids and Barriers of the CNS

JF - Fluids and Barriers of the CNS

IS - 1

M1 - 7

ER -

Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice

ASJC Scopus Subject Areas

Keywords

Access to Document

OpenUrl availability

Other files and links

Cite this