Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial

Norman Mangner; Samin K. Sharma; Chris O’connor; Amir Kaki; George D. Dangas; Jeffrey W. Moses; Ehtisham Mahmud; Giuseppe Tarantini; Stephan Achenbach; Stuart J. Pocock; William W. O’neill; Cindy L. Grines; Alexandra J. Lansky; Jason R. Wollmuth; Jagat Narula; Dimitrios I. Karmpaliotis; Haroon A. Faraz; Mir B. Mir; Aditya S. Bharadwaj; Ziad A. Ali; Chuck Simonton; Seth D. Bilazarian; Navin K. Kapur; Roberta C. Chapman; Dana Bentley; Jeffrey J. Popma; Akiko Maehara; Stephan Windecker; Gregg W. Stone

doi:10.4244/EIJ-D-25-00486

Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial

Norman Mangner
, Samin K. Sharma
, Chris O’connor
, Amir Kaki
, George D. Dangas
, Jeffrey W. Moses
, Ehtisham Mahmud
, Giuseppe Tarantini
, Stephan Achenbach
, Stuart J. Pocock
, William W. O’neill
, Cindy L. Grines
, Alexandra J. Lansky
, Jason R. Wollmuth
, Jagat Narula
, Dimitrios I. Karmpaliotis
, Haroon A. Faraz
, Mir B. Mir
, Aditya S. Bharadwaj
, Ziad A. Ali

Chuck Simonton, Seth D. Bilazarian, Navin K. Kapur, Roberta C. Chapman, Dana Bentley, Jeffrey J. Popma, Akiko Maehara, Stephan Windecker, Gregg W. Stone

Medicine

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1244-1258
Number of pages	15
Journal	EuroIntervention
Volume	21
Issue number	21
DOIs	https://doi.org/10.4244/EIJ-D-25-00486
State	Published - 2025

ASJC Scopus Subject Areas

Cardiology and Cardiovascular Medicine

Keywords

HFrEF
Impella
high-risk PCI
microaxial flow pump
prognosis
randomised controlled trial

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10.4244/EIJ-D-25-00486

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Mangner, N., Sharma, S. K., O’connor, C., Kaki, A., Dangas, G. D., Moses, J. W., Mahmud, E., Tarantini, G., Achenbach, S., Pocock, S. J., O’neill, W. W., Grines, C. L., Lansky, A. J., Wollmuth, J. R., Narula, J., Karmpaliotis, D. I., Faraz, H. A., Mir, M. B., Bharadwaj, A. S., ... Stone, G. W. (2025). Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial. EuroIntervention, 21(21), 1244-1258. https://doi.org/10.4244/EIJ-D-25-00486

Mangner, N, Sharma, SK, O’connor, C, Kaki, A, Dangas, GD, Moses, JW, Mahmud, E, Tarantini, G, Achenbach, S, Pocock, SJ, O’neill, WW, Grines, CL, Lansky, AJ, Wollmuth, JR, Narula, J, Karmpaliotis, DI, Faraz, HA, Mir, MB, Bharadwaj, AS, Ali, ZA, Simonton, C, Bilazarian, SD, Kapur, NK, Chapman, RC, Bentley, D, Popma, JJ, Maehara, A, Windecker, S & Stone, GW 2025, 'Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial', EuroIntervention, vol. 21, no. 21, pp. 1244-1258. https://doi.org/10.4244/EIJ-D-25-00486

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title = "Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial",

keywords = "HFrEF, Impella, high-risk PCI, microaxial flow pump, prognosis, randomised controlled trial",

author = "Norman Mangner and Sharma, \{Samin K.\} and Chris O{\textquoteright}connor and Amir Kaki and Dangas, \{George D.\} and Moses, \{Jeffrey W.\} and Ehtisham Mahmud and Giuseppe Tarantini and Stephan Achenbach and Pocock, \{Stuart J.\} and O{\textquoteright}neill, \{William W.\} and Grines, \{Cindy L.\} and Lansky, \{Alexandra J.\} and Wollmuth, \{Jason R.\} and Jagat Narula and Karmpaliotis, \{Dimitrios I.\} and Faraz, \{Haroon A.\} and Mir, \{Mir B.\} and Bharadwaj, \{Aditya S.\} and Ali, \{Ziad A.\} and Chuck Simonton and Bilazarian, \{Seth D.\} and Kapur, \{Navin K.\} and Chapman, \{Roberta C.\} and Dana Bentley and Popma, \{Jeffrey J.\} and Akiko Maehara and Stephan Windecker and Stone, \{Gregg W.\}",

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T2 - rationale and design of the PROTECT IV trial

AU - Mangner, Norman

AU - Sharma, Samin K.

AU - O’connor, Chris

AU - Kaki, Amir

AU - Dangas, George D.

AU - Moses, Jeffrey W.

AU - Mahmud, Ehtisham

AU - Tarantini, Giuseppe

AU - Achenbach, Stephan

AU - Pocock, Stuart J.

AU - O’neill, William W.

AU - Grines, Cindy L.

AU - Lansky, Alexandra J.

AU - Wollmuth, Jason R.

AU - Narula, Jagat

AU - Karmpaliotis, Dimitrios I.

AU - Faraz, Haroon A.

AU - Mir, Mir B.

AU - Bharadwaj, Aditya S.

AU - Ali, Ziad A.

AU - Simonton, Chuck

AU - Bilazarian, Seth D.

AU - Kapur, Navin K.

AU - Chapman, Roberta C.

AU - Bentley, Dana

AU - Popma, Jeffrey J.

AU - Maehara, Akiko

AU - Windecker, Stephan

AU - Stone, Gregg W.

PY - 2025

Y1 - 2025

KW - HFrEF

KW - Impella

KW - high-risk PCI

KW - microaxial flow pump

KW - prognosis

KW - randomised controlled trial

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DO - 10.4244/EIJ-D-25-00486

M3 - Article

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AN - SCOPUS:105023305136

SN - 1774-024X

VL - 21

SP - 1244

EP - 1258

JO - EuroIntervention

JF - EuroIntervention

IS - 21

ER -

Mechanical circulatory support in high-risk elective PCI: rationale and design of the PROTECT IV trial

ASJC Scopus Subject Areas

Keywords

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