TY - JOUR
T1 - Maternal Protein Deprivation
T2 - Changes in Systemic Renin-Angiotensin System of the Mouse Fetus
AU - Goyal, Ravi
AU - Galffy, Andrew
AU - Field, Stephanie A.
AU - Gheorghe, Ciprian P.
AU - Mittal, Ashwani
AU - Longo, Lawrence D.
N1 - Reprod Sci. 2009 Sep;16(9):894-904. doi: 10.1177/1933719109337260. Epub 2009 Jun 10.
PY - 2009/9
Y1 - 2009/9
N2 - We tested the hypothesis that maternal protein deprivation during gestation results in changes in expression of the systemic renin-angiotensin system in fetal mice. Fetal weight was decreased significantly as a consequence of 50% maternal protein deprivation during second half of gestation. In fetal liver, angiotensinogen protein expression was reduced significantly despite a significant increase in messenger RNA (mRNA). In fetal kidneys, both mRNA and protein levels of renin were increased significantly. In the lungs, we observed a decrease in both angiotensin-converting enzyme I and II mRNA expression, whereas protein expression of both isoforms was increased significantly. The fetal heart showed significant increases in expression of angiotensin II type 1 (AT-1) and type 2 (AT-2) receptors mRNA. Protein expression of AT-1 receptors increased, while that of AT-2 receptors decreased. We conclude that maternal low-protein diet during gestation leads to significant changes in expression of the systemic renin-angiotensin system in fetal mice and may be important in the genesis of hypertension in the adult. © 2009, SAGE Publications. All rights reserved.
AB - We tested the hypothesis that maternal protein deprivation during gestation results in changes in expression of the systemic renin-angiotensin system in fetal mice. Fetal weight was decreased significantly as a consequence of 50% maternal protein deprivation during second half of gestation. In fetal liver, angiotensinogen protein expression was reduced significantly despite a significant increase in messenger RNA (mRNA). In fetal kidneys, both mRNA and protein levels of renin were increased significantly. In the lungs, we observed a decrease in both angiotensin-converting enzyme I and II mRNA expression, whereas protein expression of both isoforms was increased significantly. The fetal heart showed significant increases in expression of angiotensin II type 1 (AT-1) and type 2 (AT-2) receptors mRNA. Protein expression of AT-1 receptors increased, while that of AT-2 receptors decreased. We conclude that maternal low-protein diet during gestation leads to significant changes in expression of the systemic renin-angiotensin system in fetal mice and may be important in the genesis of hypertension in the adult. © 2009, SAGE Publications. All rights reserved.
KW - Hypertension
KW - development
KW - fetal growth
KW - gene expression
UR - https://www.scopus.com/pages/publications/70350716083
UR - https://www.scopus.com/pages/publications/70350716083#tab=citedBy
UR - https://www.mendeley.com/catalogue/c8f66e5f-90c2-3d8d-8e12-716fa0964b08/
U2 - 10.1177/1933719109337260
DO - 10.1177/1933719109337260
M3 - Article
C2 - 19516079
SN - 1933-7191
VL - 16
SP - 894
EP - 904
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 9
ER -