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Lysophosphatidylcholine activates the Akt pathway to upregulate extracellular matrix protein production in human aortic valve cells

  • Hui Cheng
  • , Qingzhou Yao
  • , Rui Song
  • , Yufeng Zhai
  • , Wei Wang
  • , David A. Fullerton
  • , Xianzhong Meng

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalJournal of Surgical Research
Volume213
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

ASJC Scopus Subject Areas

  • Surgery

Keywords

  • Akt
  • Aortic valve
  • Extracellular matrix protein
  • Lysophosphatidylcholine
  • Oxidized low-density lipoprotein
  • Collagen Type I/metabolism
  • Up-Regulation
  • Signal Transduction
  • Humans
  • Middle Aged
  • Cells, Cultured
  • Aortic Valve/cytology
  • Male
  • Biomarkers/metabolism
  • Lipoproteins, LDL/metabolism
  • Proto-Oncogene Proteins c-akt/metabolism
  • Extracellular Matrix Proteins/metabolism
  • Lysophosphatidylcholines/metabolism
  • Collagen Type III/metabolism
  • Female
  • Aged
  • Aortic Valve Stenosis/metabolism
  • Biglycan/metabolism

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