LSC Abstract – The association between fine ambient particulate air pollution and lung cancer incidence in adventist health and smog -2 (AHSMOG-2) cohort study

Background: A few studies suggest an association between ambient fine particulate matter (PM ) and mortality from lung cancer (LC), but the relationship is not well established for LC incidence. Objectives: To assess the association between incident LC and PM and ozone (O ), using the Adventist Health and Smog Study2 (AHSMOG-2) cohort. Methods: A total of 80,285 AHSMOG-2 subjects were followed for an average of 7.7 years. Ambient air pollution levels at subjects' residences for the years 2000 and 2001 were linked with LC incidence data from U.S. state cancer registries. Results: A total of 250 incident LC cases occurred during 598,927 personyears of followup. Hazard Ratio (HR) with 95% confidence interval (CI) for LC incidence associated with each 10μg/ m3 increase in PM2.5 was 1.46 (1.05, 2.05) in the twopollutant multivariable model with O3. When limiting analyses to those who had lived more than 5 years at their enrollment address, the HR's became stronger with a 59% and 60% increase in incident LC for each 10 μg/m3 increment in PM2.5 in single-and twopollutant models, respectively. Conclusion: Increasing levels of ambient PM2.5 are associated with increasingly higher LC incidence. No independent effect was found with ambient O3 levels. Hazard ratios stratified by time since quit smoking for those who were ever smokers (n =135) compare to never smokers (n =115). (Figuer Presented).